Jundishapur Scientific Medical Journal
Year:2016 | Volume:15 | Issue:5|Papers Count:13

Background and Objective: Gastrointestinal complications caused by using nonsteroidal anti-inflammatory drugs (NSAIDs) motivated researchers to pay more attention to herbal medicines with anti-inflammatory effect. The aim of this study was to compare the anti-inflammatory effect of hydroalcoholic and aqueous extract of Apium graveolens with aspirin in treatment of formalin-induced inflammation in rat hind paw.Subjects and Methods: Male Wistar rats (weighting 150-180 g) were used in this study. To prepare hydroalcoholic extract, ethanol (70%) and maceration method were used and to prepare aqueous extract distilled water and maceration method were used. Animals were divided into 11 groups (6 in each). Negative control group received 5ml/kg normal saline and positive control group received 300 mg/kg aspirin. The test groups received various increasing doses of the hydroalcoholic extract (100, 200, 400, 600 mg/kg) or 100, 200, 400, 600, 800 mg/kg of aqueous extract of Apium graveolens via intraperitoneal route. Thirty minutes later all groups received 100 µl formalin 2.5% subcutaneously at the hind paw. Then, changes in the volume of rat paw were measured hourly for 5 hrs using plethysmometer..REsults: All hydroalcoholic extract treated groups showed significant difference (p<0.05) when compared with negative control group. The 100 and 200 mg/kg of extract showed anti-inflammatory effect less than aspirin at all allocated times. But there was no significant differences between the groups that received 400 and 600 mg/kg extract with aspirin group. Except for the 100 mg/kg group, all aqueous extract treated groups showed significant differences (p<0.05) when compared with negative control group. The 200 and 400 mg/kg of extract showed anti-inflammatory effect less than aspirin at all allocated times. But there was no significant differences between the groups that received 600 and 800 mg/kg aqueous extract with aspirin group.Conclusion: The hydroalcoholic extract (400 mg/kg) and aqueous extract (600 mg/kg) of Apium graveolens were as effective as 300 mg/kg aspirin in alleviating edema in rat hind paw.

Background and Objective: Exercise training based on cardiac rehabilitation can lead to improvement of cardiac function and regulatory hormones involved in blood pressure homeostasis. The aim of this study was to compare the effects of different protocols of cardiac rehabilitation on plasma levels of rennin-angiotensin enzyme system in cardiovascular patients after CABG operation.Subjects and Methods: In present semi-experimental research forty patients after CABG operation were selected targetly, and divided randomly in four groups: control (n=10), aerobic-continuous (n=10), aerobic interval–resistant (n=10), and aerobic continuous–resistant (n=10). Plasma levels of angiotensin I, angiotensin II, and ACE-2 were measured by ELIZA method before and after cardiac rehabilitation protocols. Two way ANOVA used for statistical analysis (P<0.05).Results: Following implementation of cardiac rehabilitation protocols, a significant decrease in angiotensin II and a significant increase in angiotensin I were found in comparison with control group (P<0.05). But there were no significant differences between intervention groups (P>0.05). After cardiac rehabilitation periods there were no significant differences between ACE-2 levels among control and intervention groups (P>0.05).Conclusion: Cardiac rehabilitation programs with consumption of AT1R Inhibitors drugs such as: Losartan, are important way for improvement in cardiovascular function and blood pressure reduction.

Background and Objective: Patent ductus artriosus (PDA) accounts for 8-10% of congenital heart diseases. Patency of this ductus after birth can induce heart failure or endartritis. For these reasons closing of this duct is suggested by surgical or interventional approaches. The purpose of this study was to evaluate the rate of success of closing PDA by interventional approach in Shahid Chamran hospital in Isfahan University of Medical Science.Subjects and Methods: Thirty nine patients (18 male and 21 female) and their PDA was diagnosed by echocardiography were the subjects of this study.Results: Mean weight of patients was 10.82±6.43 Kg. Mean age of patients was 14.3±11.8 months. In 15 patients coil and in 24 patients Amplatzer used for closing of PDA. In 10 patients Cook coil and in 5 patients Pfm coil were used. Mean size of PDA in narrowest size at the pulmonary artery was 3.2±1.7 mm. The mean time of angiography was 45.3±12.2 min and for fluoroscopy was 8.5±6.3 min. No acute complications such as death, severe bleeding, vessels rupture or arrhythmia were encountered. In addition, no late complications such as stenosis in aorta or pulmonary arteries, migration of devices, fracture or deformity of devices or residual shunt were found.Conclusion: Our experience in this center showed that interventional approaches for closing of PDA are safe.

Background and Objectives: Performing body activities such as eccentric exercises have positive effect on weight loss but canalso lead to increasing muscle injury and increase in inflammatory indices and enzymes in the blood. Ginger supplement reduce inflammation and pain. The aim of this study was to investigate the effect of short-term consumption of ginger supplementation on serum levels, high-sensitivity C-reactive protein (HSCRP) and creatine kinase (CK) resulting from eccentric exercise.Subjects and Methods: In this quasi-experimental study, 22 overweight female student from Shahid Chamran University were randomly divided into two groups supplement (n=12, the age range 25.75 ± 0.46, BMI 27.32±0.43) and placebo (n=10, the age range 25.90±0.70, BMI 26.11±0.69). Supplement group consumed or before food 2 g of supplement ginger powder daily for two weeks. The exercise protocol performed including two exhaustive eccentric exercise (negative slope on a treadmill, one session before one session after two weeks of supplementation) with an initial speed of 4 mph and an initial gradient was 2%. The t-test and analysis of variance were used by analysis.Results: The results showed that eccentric exercise increased levels of HSCRP and CK after the exercise activities (P<0.05). Two weeks of ginger supplementation had no significant effect on the levels of HSCRP and CK (P≥0.05).Conclusion: The daily consumption of ginger supplements can reduce inflammation and muscle damage caused by exercise.

Background and Objective: Simulation using Monte Carlo technique is a practical method for assessment of the characteristics of the clinical photon beam from the treatment head. The accuracy of the simulation results is based on the validation of the Monte Carlo models used in the calculation. This study validated the simulation with BEAMnrc code for 6MV energy.Subjects and Methods: The accelerators of Varian Clinic 2100C/D for photon beam 6MV were simulated using the BEAMnrc code system. A cylindrical mono energetic with 5.7, 5.9, 6 MV energies and 1, 2, 3 mm radius were applied. Two phase space files were scored below the exit window and above the phantom then analyzed the beam characteristics using BEAMdp and calculated the percentage depth dose and profile at 10cm using DOSXYZ code. In this work, measurements were performed using 0.13 cc ion chamber inside a water phantom with dimension 50×50×50cm3. At the end of simulation, the results of the measured data were compared using gamma index with criteria 2%/2mm.Result: By increasing the electron energy, percentage depth dose in buildup region was reduced and became closer to measurements. With increasing the diameter of the electron source, the photons were diverged and the edges of the profiles showed a sharp drop compared to the dose measurements.Conclusion: Finally good agreement (gamma index within2%/2mm) between the measurements and simulations was achieved for field sizes of 4×4 ،10×10 and 30×30cm2 with radial of incident electrons 0.2cm at source surface distances of 100cm.

Background and Objective: Creating a reliable vascular access (VA) is the most important determinant for effective hemodialysis (HD). The ideal long-term VA is arterio-venous (AV) fistula. This study was undertaken to compare and determine the impact of timing of the AV fistula creation on its outcomes.Subjects and Methods: In this interventional-comparative study a total of 168 ESRD patients referred by nephrologist for VA creation, to the vascular surgery clinic of Ahvaz Golestan Hospital from 1 Nov. to 31 May 2015-2016 were included in two 84-memberd groups. The late group in whom HD has been already started by double-lumen (DL) catheter and the early group in whom HD has not been started yet. they were followed prospectively and a complete data about their HD and VA were gathered. .Results: The mean duration of follow up was 16±2 weeks. The incidence of complications was higher in late group (42 (50%) vs 22 (26.1%), P<0.01). Non-maturing and thrombosis of fistula occurred more frequently in late group (34.5 % and 21.4 %) vs (8.3 % and 6%) respectively (P<0.01). Nearly all the deaths occurred in elderly patients with high incidence of major comorbidities.Conclusion: Early placement of VA before HD start, except perhaps in elderly with multiple comorbidities, is reasonable and is associated with higher success rates. In addition, complications can be remedied without the need for catheter thus improving the survival of the VA and quality of life in ESRD patients.

Background and Objective: Hypertension (HTN) is a systemic disease that different agents affect its incidence. This study is designed to determine HTN correlation with the height and weight of children.Subjects and Methods: This is a prospective analytic-descriptive epidemiological study in which the studied population were Ahvaz’s students aged 7-11 years old. Five thousand eight hundred eleven students (2904 male and 2907 female) were sampled by randomized systematic method. The weight, height, systolic and diastolic blood pressure were statistically analyzed with pearson and regular regression.Results: The minimum of systolic blood pressure was 57.5 mmHg, maximum was 125 mmHg. The mean blood pressure was 101.41±8.97 mmHg. The minimum of diastolic blood pressure was 44.5 mmHg, maximum was 85 mmHg and mean was 62.51±6.55 mmHg. Also, the correlation between systolic and diastolic blood pressure with height and weight was significant.Conclusion: This study showed that several factors affecting blood pressure in children, particularly diastolic blood pressure, which most important of them including age, height and weight.

Background and Objective: This study aims to evaluate the effectiveness of health promoting lifestyle group training on vitality, pleasure and social adjustment among women with type-2 diabetes in Esfahan city in 2014.Subjects and Methods: This was a quasi-experimental study with pretest experimental and control groups. . Deci and Ryan Vitality Scale, Hamilton Pleasure Scale Asnyt and compatibility Bell were used in this work. For the implementation on the experimental group, lifestyle intervention group training health promotion On lifestyle and Walker 6-health promotion theory in physical and mental health 8 sessions 90 min as were the control group received no intervention. The test and multivariate analysis of covariance revealed that educational intervention promote the healthy lifestyle.Results: Results showed implementation of significant increase in vitality, pleasure and social adjustment in women with type 2 diabetes (p<0.001).Conclusions: This study emphasizes the role of health promoting lifestyle in improving and control of type II diabetes and increases vitality, pleasure and social adjustment in these patients.

Background and Objective: Diabetes increases oxidative stress in different tissues and leads to increased levels of oxidation of DNA, proteins and lipids. Paraoxonase is an esterase enzyme that is carried along with HDL-C. This enzyme prevents of the peroxidation of LDL-C and therefore effective in reducing the risk of atherosclerosis.Subjects and Methods: In this clinical trial study the subjects of this research included diabetic postmenopausal women in the city of Babol with the age range between 50 and 60 years old. Who were selected with coordination of Diabetes Association. The statistical sample included 33 subjects who were randomly divided into four groups (n=7 to 9). These groups were randomely divided into: control, pomegranate juice, exercise and exercise-pomegranate juice. Program of aerobic training groups was for six weeks, three times in a week and for 45-65 minutes/day and in four afternoon was carried out. Subjects consume 150 ml of pomegranate juice daily at eight o'clock every morning.. For the analysis data from the Dependent t-test and analysis of variance one way ANOVA was used.Results: There was a highly significant increase in the paraoxonase-1 (P<0.05) and HDL, as well as a significant decrease in levels of TG, TC and LDL (P<0.05) before and after the experimental period in the group of subjects.Conclusion: activity of paraoxonase enzyme and Plasma lipid profile can be influenced by dietary factors and lifestyle.

Background and Objective: Because most patients with back pain wish to treat themselves by noninvasive techniques, the purpose of this study was to compare the effectiveness the exercise therapy and selected yoga exercises on chronic low back pain.Subjects and Methods: In this semi-empirical and applied study, 45 female patients of Najafabad city with inclusion criteria and diagnosis of chronic low back pain were selected for entry into the study. The subjects were randomly divided into three equal groups: control, exercise therapy and selected yoga exercises. Pain intensity as the pre-test and post-test were measured using the visual analogue scale (VAS). Exercise and yoga treatment protocol during 3 months (3 sessions/ week for 12 weeks and 60 min duration) was performed on the test groups. Duirng this period, the control group did not perform any treatment. Data were analyzed by SPSS software 16 and presented with t -test, one way ANOVA and LSD.Results: Both selected programs of exercise therapy and selected yoga exercises had meaningful effects on reducing low back pain (P<0.05). There was no significant difference between their impacts on reducing chronic low back pain, (P>0.05).Conclusion: Both exercise therapy and selected yoga exercises treatments can be effective for reducing chronic low back pain.

Background and Objective: Outspreaded of modern life style causes increasing consumption of carbonated beverages. Vickers hardness measurement is one of the most practical methods to determine the microhardness of the teeth enamel. The aim of this study was to determine the effect of some of the common carbonated beverages in Iran on the microhardness of the human extracted teeth enamel in Yazd dental clinics.Subjects and Methods: In this experimental in-vitro study, 60 anterior and posterior human teeth were collected and surface preparation of the samples for measuring Vickers hardness was done and enamel blocks were divided into 6 groups:1-Limon Delester, 2-Orange Miranda, 3-Pepsi, 4- Carbonated Doogh, 5-Sprite and 6-physiologic serum (control group). Samples were kept in each group 6 hours per day for one week. This study was microhardness analyzed in 3 stages (Initial, after one day and at the end 7 day). Microhardness was measured with MH1 (Iran-Sari) Vickers hardness measurement. Finally data were analyzed with SPSS17،T-tests،ANOVA،TukeyHSDand Repeated measure statistical tests.Results: Tukey HSD test showed at the beginning groups did repeated measure not have a significant difference and after one day the first studied five groups had a significant difference with the control group. ANOVA test and p-values showed that microhardness after one day and at the end 7 day in studied groups, significantly decreased. (P-value<0.05). ST test of time in terms of overall Repeated measure was significant, and interaction between time and group by (P-value <0.001) were significant. .Conclusion: This study showed that common carbonated beverages in Iran have significantly decrease the enamel hardness after one day and at the end 7 day P <0.05 and their consumption should be spread with a safer potential.