The objective of the present study was to examin the effectiveness of group contracting and behavioral activation therapy (GCBAT) in the treatment of opioid use. In this clinical trial study, 120 patient with the diagnosis of opioid dependence based criteria were assigned randomly to four groups in methadone maintenance treatment: (A) Cognitive- behavioral Therapy (CBT), (B) GCBAT, (C) GCBAT plus family support education (FSE) for this group family members, and (D) methadone alone. The two experimental groups (A and B) had 890 minutes weekly session of group therapy, the CBT group (A) had 12 two hours weekly session of group therapy and the methdon group (D) took methadone only. All participants completed the Mental Health Inventory (MHI) and Opioid Treatment Index (OTI) at baseline and again 5 months after group psychothempy. Treatment data were anlaysed by using univariate analysis of variance repeated measurements and chi-squre test. Finding in the three experimental groups showed a decrease in drug use, social dysfunction, illegal behaviors, psychological distress and increase in health factors and psychological well-being. Results showed: GCBAT, GCBAT-FSE and CBT have superior from to methadone group in (MHI) and (OTI) scales. GCBAT-FSE superior from to GCBAT, CBT and methadone group in relapse prevention and remain on treatment after of relapse.