In Islamic philosophy before Mulla Sadra epistemology was not principal concern of philosophers, and what they have said in this matter was in relation to other problems. First Mulla Sadra take this problem seriously and after examining sayings of prior philosophers, theorizes about it. Epistemological theory of Mulla Sadra consists of three fundamental elements: scientific forms or images (object per se), the subject (soul), and mutual relations that scientific forms acquire in process of knowing. On the one hand, scientific forms represent beyond themselves and are intermediaries of our knowledge of other things. and on the other hand, they are in relation to the subject and are acquired in soul. Mulla Sadra has novelties about all above-mentioned elements, and from all of them has made a novel and powerful theory of knowledge. While Mulla Sadra theorizing is coherent with his system of philosophy, his theory lacks coherent justification. This diverge view of commentators on his theory. Assumption of this essay is that Mulla Sadra system of philosophy has necessary tools and possibilities for justifYing his theory. Hence, in this essay, at first we briefly introduce epistemological theory of Mulla Sadra and compare it with theories of prior muslim philosophers, and then reconstruct its reasons, It must to be said that part of Mulla Sadra theory that was more challenging, ie, relation of scientific forms with soul, is principal concern of this essay.