Padena area of Semirom is located in southern Isfahan province with an area of about 70 km2. Every year many landslides occur in this area and cause damages to the only road connecting Sarbaz and Dashtbal villages. In this article, geographical information system and ILWIS programs were used to evaluate the effective factors causing landslides, and appropriate stabilization methods were recommended. After preparing a landslide distribution map, the effective factors in occurring landslides such as lithology, distance from drainage systems, slope, annual precipitation, distance from road, vegetation and distance from fault were evaluated, and finally a landslide hazard zonation map was prepared.The results indicate that about 40% of the landslides were located in the very high potential landslide zone, 26% in the high potential, 20% in the medium potential and 14% in the low potential zones. At last, preventive methods, such as using gabion and huge rock size in slopes adjacent to rivers, reduction of sharp slopes with attention to lithology of marble, using detour channels with attention to the meandrous shapes of rivers, using surface drainage systems with dendritic shape for rapid drainage of surface water, and vegetation management were recommended.