One of the issues encountered by the Iranian Humanities and Social Sciences Society is the commercialization of knowledge and business creation in this field. As a result, the deprivation of business areas from the benefits and capacities of the humanities and social sciences, the wasting of the country's capital, the unemployment of a large number of graduates, immigration and employment in irrelevant businesses are the main consequences of this issue. Therefore, this paper attempts by reviewing the literature on entrepreneurship, the supporting ecosystem of entrepreneurship and the study of two domestic and international universities, provide some solutions for developing university entrepreneurship in the field of humanities and social sciences. The results show that in comprehensive universities, firstly, engineering faculties and then social sciences, economics and management schools engage in entrepreneurship. However, other colleges are resisting entrepreneurship. Therefore, at a humanities university, the stimulation of all faculties for entrepreneurship innovatively, along with the pursuit of scientific and research tasks, should be carefully addressed and start with the colleges whose products and services are closer to the market. In addition, there is no universal framework for creating an academic entrepreneurship ecosystem. Thus, the officials of the universities in the field of humanities must be able to create a environment in which, while preserving the traditional values of education and research, put the commercialization capacity of creating entrepreneurial culture in the university at the center of attention of students and staff.