The Renaissance was the start of a new age of science, creativity and critical thinking in the West, however, the research methods and perspectives have been prevailed since the early twentieth century. Nevertheless, the Muslim scholars in the glorious age of Islamic civilization have had their own methods and insights. Muhammad ibn Zakariya Razi(Rhazes) was a great Iranian physician who used the particular research methods and approaches in his works which can be compared with his European counterparts in the seventeenth and eighteenth centuries AD. Rhazes composed his valuable works by his mastermind and critical gift as well as putting emphasis on the clinical observations and experimental techniques to explore the medical science. He used the research methods such as expression of the study, aim of research, question and hypothesis, sources criticism, introduction, discussion and conclusion that are common today. This article examines the major works of Rhazes in medicine, presenting the examples of his research methods and perspectives that are much beyond his age and similar to today.