The literature on university entrepreneurship and entrepreneurial university is rapidly expanding. Universities in developed countries have become increasingly entrepreneurial. In knowledge-based economy, universities in addition to their traditional missions like education and research have been involved in their third mission including innovation process and technology development. In this respect, new networks related to universities are grown and universities regarding their capacities as generators and distributors of knowledge, in the form of entrepreneurial universities play their crucial roles in industrial innovation, technology development, job creation and prosperity as well. In this regard, the new age faces huge developments in academic systems to be in line with indigenous, regional and international economic development. Therefore, the overcoming approach of educational and research activities, is demand oriented in relation with peripheral organizations. If mutual relations of academic environment with external organizations including firms are organized with effective mechanisms, its result will be job creation, prosperity and more productivity of human and non-human resources.This paper aims to express the modern entrepreneurial roles of academics, explain the evolutionary process of the knowledge production styles including global experiences, academic entrepreneurship models and mechanisms first, then tries to draw a framework to expand the academic entrepreneurial activities for technology development, job creation and prosperity.