To investigate the impact of drought stress and spraying the micro-nutrients of zinc, iron and manganese on the quantitative and qualitative traits of sunflower, highsun 33, an experiment was carried out in complete random blocks with three replications in 1384 in the research agricultural center of W. Azarbaijan- Khoy. The irrigation treatments included I1 (non-irrigation in the stage of pollination), I,2 complete irrigation every 8 days) I,3 (spraying in the stage of anthodium appearance) which were considered as the main factors and stages of spraying micronutrients including F1 (spraying in the stage of plate formation) F2 (spraying in the first stage of pollination) F3 (spraying in plate appearance and beginning of pollination), and F,0 (without spraying) were taken as sub-level factors. The experiments showed that the effects of irrigation and spraying had significant impact on all the studied traits like the height of the shrubs, plate's diameter, number of grains in the plate, weight of 1000-grain, biologic yield, and oil. Also mutual irrigation and spraying stages showed the highest impact on the diameter of the plate, the number of grains in the plate, grain yield, and oil. The treatment usage of I, 2 F3 and I,3 and F0 produced the highest grain and oil yield of 6.17 and 2.95 tons per hectare. The lowest, 2.16 and 1.06 tons per hectare respectively. The application of spraying reduced the impact of drought stress in most studied traits, especially grain and oil yield. It was shown that the spraying of micro-nutrients, especially in drought stress condition had remarkable role in reduction of negative effects of drought and the improvement of yield and its component in sunflower.