The aim of present research was to study the prediction equation between personality trait and life style and marital satisfaction among woman nurses. The research method was descriptive-correlational. The target population included all married woman nurses working in hospitals in Shiraz. A sample of 140 respondents was drawn through cluster random sampling method. The instruments were NEO inventory, Miller & Smith’s Life Style Questionnaire, and Enrich’s Marital Satisfaction Questionnaire. A use was made of descriptive statistics, Pearson correlation analysis, and multiple regression analysis in order to analyze data using SPSS. The findings showed that there was a negative relationship between neuroticism and marriage terms, whereas, a positively significant relationship was indicated between agreeableness and life style and marital satisfaction. It was also found that there was no significant relationship between extraversion, openness, conscientiousness, age, and marital satisfaction. Other results showed that neuroticism, agreeableness, life style and marriage terms could meaningfully predict marital satisfaction, while, extraversion, openness, and consciousness as personality variables and age could not significantly account for the variance.