During May 1998 up to October 2002, serotyping and antibiotic sensitivity of salmonellae isolates from commercial chickens and domestic pigeons submitted to Razi fustitute were carried out. One hundred-eleven salmonella salmples were isolated from commercial chickens affected by yolk sac infection, growth retardation, arthritis and respiratory sings and from domestic pigeons suspected to salmonellosis using standard methods. One hundred-eleven salmonellae were serogrouped and serotyped with specific antisera.Salmonellae isolates belonged to serogroups D1(84.26%), B(8.33%) and C1(7.41%). The salmonella serotypes isolated from chickens were enteritidis (78.7%), typhimurium (7.4%), S.II belonging to
serogroup Cl (3.7%), nigeria (2.8%), rostock (1.85%), Montevideo .93%), eko (.93%), naestved (.93%), moscow (.93%), blegdam (.93%) and S.II belonging to serogroup D1 (.93%). Two isolates from
pigeons were S. enteritidis and one isolate was S.II belonging to serogroup C1. The isolates were tested for drug sensitivity with 32 different antimicrobials. All of the tested Salmonella were resistant to lincomycin, novobiocin, erythromycin, penicillin, bacitracin, tylosin, tiamulin and all of the tested salmonella were susceptiple to ciprofloxacin, ceftriaxone, ceftiofur, ceftizoximeand flurphenicol. The percentages of salmonella susceptible to amikacin, chloramphenicol, gentamicin,linco- spectin,sulfamethoxazol-trimethoprim, flumequine, streptomycin, neomycin, enrofloxacin, furazolidone, cephalexin, nalidixic acid, doxycycline, oxytetracycline, tetrcycline, nitrofurantoin, amoxicillin, ampicillin furaltadone and colistin were 97.6% , 92.3%, 92.1%, 84.7%, 83.3%, 65.6%, 64.9%, 63.6%, 61.8%, 46%, 44.9%, 25.4%, 20.5%, 20%, 19.8%, 16.4%, 12.4%, 11.1%,4.7% and 1.5%, respectively. Because of the increased acquired resistance against the regular antibiotics, medication alone is not enough to control the salmonella infections in poultry and even causes problems in poultry industry and public health.