Introduction: Absence and the tendency to be absent from university classes, while reducing internal and external effectiveness of the university system, have numerous individual and social consequences that make studying this issue necessary. Given that human behavior is a multivariate product, the diverse causes of university absenteeism as a human behavior can be studied from different angles. Some of the reasons for being absent from university classes are rooted in the educational system. The purpose of this study was to study the role of educational system variables in the students of Hamadan University of Medical Sciences on university absenteeism (absenteeism and tendency to absence).Methods: The research project is a descriptive-correlational research project. The statistical population included all students of Hamadan University of Medical Sciences. The sample size of the study was 306 people, using a Morgan table. Data were collected randomly by stratified random sampling method. The data collection tool was a researcher made questionnaire.Results: According to the findings of the research, there is a negative relationship between university absenteeism and variables of content usefulness perception, teacher teaching method, fair evaluation, human relationships in the educational environment, staffing and welfare services provided to students. Based on the results of hierarchical regression analysis (step by step), faculty competency, fair evaluation and welfare services are reliable predictors of university class absenteeism and explain more than 18% of the variance of this variable.Conclusions: According to the findings of this study, despite the various individual and social factors affecting the university absenteeism, part of the absenteeism factors are due to the variables of the academic system, (in this study, the competence of the faculty members, fair evaluation and welfare services). Therefore, university administrators should pay attention to planning issues such as: improving faculty members and improving quality of welfare services, to reduce the negative role of the university system in university absenteeism.