Multiple sclerosis disease can affect the quality of life of patients. The present study investigated the role of perceived social support, coping strategies and resilience in the prediction of the quality of life in patients with MS. This was a descriptive correlation study. A convenient sample of 100 patients referred to the Association of East Azarbaijan province were selected for the study. Data were collected using multi-dimensional scale of perceived social support, Coping Styles questionnaire, Resilience Scale, and Quality of Life Questionnaire. For the analysis of data Pearson's correlation coefficients and multiple regression analysis were used. Results show a significant positive correlation between different aspects of perceived social support, coping strategies and resilience and the quality of life. Furthermore, findings indicate that quality of life can be predicted by perceived social support, coping strategies and resilience. The amount of perceived social support, coping strategies and resilience patients with MS disease can influence their physical health. Therefore, training in the use of appropriate coping strategies, increasing resilience and positive cognitive changes to perceive social support correctly, can be effective in increasing the quality of life for these people.