This study evaluates the role of personality characteristics and body image in predicting quality of life in female students with anorexia nervosa. This study is a correlational predictive type of study. The sample consisted of 60 students with anorexia nervosa selected from a random sample of all female students of Islamic Azad University, Ardebil. Data were collected using Ahvaz Eating Disorders Questionnaire, Quality of Life Questionnaire, NEO Personality Inventory, and Body Image Scale. Data were analyzed using correlation and regression analyses. Based on Pearson's correlation coefficient, extraversion, agreeableness, conscientiousness, appearance evaluation, appearance orientation and satisfaction with body parts, were positive correlated with quality of life and openness, neuroticism, preoccupation with body weight and perceived weight category were negative correlated with quality of life (p<0.01). Results of multivariate regression analysis showed that extroversion and neuroticism as well as satisfaction with body parts and preoccupation with body weight were the strongest predictors of quality of life in students with anorexia nervosa. These findings indicate that personality traits and body image may be among the important components that are predictive of quality of life in people with anorexia nervosa.