The purpose of this research was to investigate the effects of neuro -linguistic programming on the depression reduction of the accounting students studying in Shahrekord Islamic Azad University. Four hundred accounting students out of 1400 were randomly required (through cluster sampling) to answer Beck’s Depression inventory (BDI). Then, 52 students scoring higher than 20 were randomly selected and placed in 4 Experimental and Control groups. The Design of the study was pre-test post-test with control groups. Experimental groups were exposed to 8 sessions of neuro-linguistic programming while the subjects in control groups received no treatment at all. The results suggested that Firstly: the co Variance (F=9.723, α<.001) showed that neuro-linguistic programming had a significant effect on the subjects in experimental groups. Secondly, running the CoVariance (F=12.042, α=.002) indicated that the independent variable ,i.e. neuro-linguistic programming did have effect on male students. Thirdly, neuro-linguistic programming proved to be effective on female students with Co Variance (F=18.398, α<.001). Since there is a direct relationship between this program and the daily life, it is supposed-through changing in one’s living procedures, his attitude towards life, and people understanding–to make a difference. Because of its practical, applied, simple, and understandable principles, neuro–linguistic programming has been able to reduce the students’ depression.