In order to evaluate the effect of elimination of one or two irrigation circuits on yield and yield components of wheat cultivars at the end of growth season and to select the best cultivars for optimal production, an expriment was conducted in 2008-2009 in the field of educatioal center of Jahad-Keshavarzi –Fars province, (Pasargad city). The study was conducted as a split plot in randomized complete blocks design with three replications. Irrigation treatments within three levels as the main plots which included: complete irrigation (control), elimination of the latest irrigation (ripening stage of seed), and elimination of two latest irrigations (flowering stage) and wheat cultivars [Bahar, Pishtaz, Chamran, and Shiraz] were used as subplots. The results showed that irrigation treatments had significant effects on grain yield, 1000 seed weight, biological yield, harvest index, so there was a highly significant difference between the elimination of two latest irrigation treatments and the two other irrigation treatments which caused significant reduction in grain yield, 1000 seed weight, biological yield, and harvest index. Grain yield and other traits were higher for control treatment of irrigation. There were significant differences for all traits between wheat cultivars and the highest values for grain yield, 1000 seed weight, biological yield, harvest index, the number of spikelets per m2, belong to Chamran and Pishtaz cultivars. Evaluation of resistance or sensitivity of wheat cultivars to drought stress at the end of growth season showed that elimination of one latest irrigation for Pishtaz cultivar and of two latest irrigation for Chamran cultivar may be possible and these cultivars were the most resistant cultivars and Shiraz and Bahar cultivar were the most sensitive cultivars.