Globalization is the process of intermingling and integrating national economies with the global economy, which has been advised by policy -makers and planners in recent decades. This study investigates the trade openness effect on economic growth in 14 selected Middle Eastern countries over the period 1990 to 2012. For this purpose, Generalized Method of Moments (GMM), Full Modified- Ordinary Least Square (FMOLS) and Dynamic Ordinary Least Square (DOLS) are used. The results demonstrate that there is a significant positive relationship between trade openness and economic growth; so that trade openness has had a positive impact on the selected countries' economic growth, and trade restrictions slow down the economic growth.According to the obtained results, investment, active population and human capital, each has a positive and significant effect on the growth (dependent variable). In other words, the role of education in improving labor productivity and its impact on economic growth based on the research results are undeniable. The results of the estimation of FMOLS and DOLS methods also confirmed the results of GMM method. The only difference between the three mentioned methods is the intensity influence of the explanatory variable on dependent variable. Hence, it is recommended that policy- makers provide the necessary grounds for expanding economic cooperation, and as well asimproving the processes and simplification the export and import laws (trade policies), provide the possibility of exchanges trade development.