Introduction: In marriage life welfare is not easily accessible. To achieve this goal, couples have to invest in advance in this matter; otherwise, happiness is not achievable. In these study criteria of spouse selection has been determined in the boy and girl students in the Zabol University of Medical Sciences in 2008.Materials and Methods: This research is a descriptive, cross-sectional study. Population of this research was 384 boy and girl students of Zabol University of Medical Sciences in the academic year of 2008. Students are selected from different academic.The answers of students to questions regarding factors that influence the spouse selection have been collected. Investigated factors were education, beauty, religious beliefs, income, spouse occupation, and the amount of dowry. The results of the study analyzed in two genders separately. Data collection was prepared by researcher-made questionnaires that composed from 21 questions. Data were statistically analyzed by Chi-square test using SPSS software.Results: chi-square test showe that almost all of the criteria of spouse selection were significantly were correlated to the gender of the students, else religious beliefs) p<0.05). The most significant difference between answers was found in the beauty and the spouse occupation that were more important for boys and girls, respectively.Conclusion: Results obtained in this study demonstrate that in girl groups, criteria of spouse selection changed with level of education. In more educated girls, the importance of partner education level is less. Conversely, in boy group no correlation found between education levels of this group and selection criteria.In more educated girls, the impotence of beauty as a partner selection criteria has not been significant. However, in more educated boys, beauty was a significant selection criteria for spouse selection. Similar religious believes in partners was one of the important criteria in spouse selection.