In order to study the effect of vermicompost produced from cow manure impregnated to copper oxide and zinc oxide nanoparticles on someproperties of wax bean crop (Vigna unguiculata), an experiment factorial were done based on a randomized complete block design in three replications. The experiment factors were as follows: nanoparticles (0, 0.4, 0.8 and 1.2 g/kg weight of substrate), vermicompost (2.5, 5 and 7.5 g/kg weight of substrate) and kind of nanoparticles(copper oxide and zinc oxide). After preparation of substrates, to any one of them was added adult worm Eisenia fetida and after a week were added nanoparticles to substrate as a solution. After three months, vermicompost prepared according to the weight of cultivation substrate was cultivated with mix soil and grain of wax bean as a wet planting. Results showed with increasing in both nanoparticles decreased spad leaves chlorophyll, number grain in pod, number of pod in bush, weight of pod, pod length, weight of hundred grains, grain yield, biological yield, harvest index, stem length and grain protein and increased concentration copper and zinc in grain. In similar level nanoparticles (except first level), spad leaves chlorophyll, number of pods, weight of hundred grains, grain yield, stem length and pod length in zinc oxide nanoparticles were more than copper oxide nanoparticles. In similar level nanoparticles and vermicompost accumulation of zinc in grain was more than copper. With comsumption of copper oxide nanoparticles, grain yield decreased 66 percent and With comsumption of zinc oxide nanoparticles, grain yield decreased 35 percent.