The aim of this study was to determine the predictive role of Behavioral Inhibition/Activation System (BIS/BAS) and dispositional mindfulness on the quality of life of middle school bright children. In a descriptive-correlational, cross-sectional and retrospective study, 120 bright students from middle schools for talented students in Tabriz, were selected by simple random sampling. Kentucky Inventory of Mindfulness Skills (KIMS), Quality of Life Scale, Behavioral Inhibition/Activation System and Raven' s Progressive Matrices were used to collect the data. The data were analyzed by using Pearson correlation coefficient and multivariate regression analysis. The results showed that the quality of life had a significant relationship (p<.01) with behavioral inhibition and behavioral activation system as well as dispositional mindfulness (observing, acting with awareness and non-judgment, and acceptance of experiences).29% of the variance in the quality of life was explained by the research variables.12% of the variance was explained by the BIS and BAS and 17% by observing, acting with awareness and non-judgment, and acceptance of experiences. According to the results, it can be concluded that brain/behavioral systems and dispositional mindfulness are essential determinants of the quality of life in the talented students.