Jundishapur Scientific Medical Journal
Year:2022 | Volume:20 | Issue:6|Papers Count:14

Background and Objectives: Hypertension is the most important risk factor for death and Cardiovasculardiseases (CVDs). Blood was referred to the clinic of Shariati Hospital in Isfahan in 2017-2018. Methods: Hypertension is the most important risk factor for death and CVDs. Blood was referred to theclinic of Shariati Hospital in Isfahan in 2017-2018The present study was a clinical trial with a pre-test and post-test design with a control group. 90 patientswith hypertension referred to the internal clinic of Shariati Hospital were randomly divided into twogroups of 45 people (control and intervention). The intervention group, training based on health beliefmodel and the control group performed routine training. Data collection tools included a health beliefmodel questionnaire, a pamphlet and an educational booklet that was presented to each member ofthe individual education intervention group in two sessions two months apart. In the second visit, bloodpressure of all patients was taken by the student and questionnaires were completed by the patientsafter the intervention. Results: The results showed that there was a statistically significant difference between the mean of themain indicators of sensitivity, severity, benefits and barriers in the intervention and control groups beforeand after the intervention (P<0. 05). Conclusion: It seems that the health model is effective in controlling blood pressure in patients withhypertension.

Background and Objectives: Research on food polyphenols has experienced a huge development during thelast century. Most studies on polyphenolic compounds have focused on extractable polyphenols (EPP). However, an important polyphenolic fraction is ignored (Non-Extractable polyphenols (NEPP)) because they aretrapped in the corresponding extraction residues. In this study, the antioxidant EPP and NEPP of sour orangepeel, extracted by aqueous solvent and acid hydrolysis (with two different solvent systems) respectively, areevaluated and compared. Methods: Antioxidant activity was evaluated by four tests of radical inhibition of 2, 2-diphenyl-1-picrylhydrazyl(DPPH), 2, 2-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), ferric reducing antioxidant power (FRAP)and iron chelating. The amount of polyphenolic compounds, flavonoids, oligomeric proanthocyanidins, andflavanones were respectively determined by folin-ciocalteu, Aluminium chloride (AlCl3) and Ultraviolet–, visiblespectroscopy (UV-visible). Also, the anti-lipid peroxidation effect in rat liver was measured. Results: The results of antioxidant analysis showed that NEPP with methanol/Sulfuric Acid Solvent had thehighest level of antioxidant activity in sour orange peel. It can be due to the high polyphenolic compounds inthis extraction compared to the others. Conclusion: All extracts had antioxidant activity and can be suggested as a potential natural source in food andpharmaceutical industries.

Background and Objectives: Coronavirus disease is a large family of viruses and subtypes of coronavirusthat range from the common cold virus to more serious illnesses such as SARS, Mers, and Covid. Symptomsof a new coronavirus that causes Coronavrus Disease 2019 (COVID-19) usually begin a few daysafter a person becomes infected with the virus. But in some people, the symptoms may appear a littlelater. According to statistics and research, symptoms can include fever (in 43. 8% of people at admissionand 88. 7% in hospitalized), dry cough, and shortness of breath. In addition to these clinical symptoms, after exposure to the virus, a series of blood factors change, and the measurement of these factors helpsto treat and prevent the progression of the disease. This study aimed to investigate the changes in variousblood factors in coronary patients admitted to Imam Khomeini Hospital in Selseleh, Lorestan. Methods: In this study, biochemical tests of 50 coronary patients, including 30 males and 20 females rangingin age from 30 to 90 years, were performed. Factors examined included White blood cell (WBC), Redblood cell (RBC), hemoglobin, platelets, lymphocytes, Erythrocyte sedimentation rate (ESR), C-ReactiveProtein (CRP), Lactate Dehydrogenase (LDH), and Creatine kinase-MB (CK-MB). Results: The results showed that among the mentioned factors, the number of lymphocytes in all patientsdecreased compared to the normal range, and the amount of ESR, CRP, CK-MB, and LDH factorsincreased compared to the normal range. Conclusion: Considering that the present study was performed at the beginning of the corona disease andthe number of hospitalized people as well as hospital facilities was low, it is better to study the populationin relation to a much larger population and also perform more complementary tests to conclude toconclude and evaluate the relevant parameters and the relationship between the parameters.

Background and Objectives: Lead poisoning is a life-threatening condition due to its acute and chroniceffects. Therefore, preventive methods are very important to prevent the multiple toxic effects of thismetal. Due to the lethal effects of lead and its increasing concentration in the environment, this studywas designed and performed to measure the concentration of lead in the blood and tissue of patientsundergoing appendectomy and cholecystectomy. Methods: In a cross-sectional study that was performed on patients with appendectomy or cholecystectomyin Razi Hospital in Ahvaz during a period of twelve months from May 2019 to May 2020. Weexamined 120 patients in three groups of appendectomy (n=40), cholecystectomy (n=40) and control(n=40). Blood samples were taken from all three groups. Then, after the operation, a pathology samplewas taken from the appendix or gallbladder from patients in two groups who underwent appendectomyand cholecystectomy. X-ray Imaging was used to check for lead. Results: Our results show well the mean blood lead concentration in the appendectomy group. In thecholecystectomy group and in the control group, the difference between the three groups was statisticallysignificant (P<0. 001). Also, lead was found in 21 samples (52. 5%) from the appendectomy groupand lead in 23 samples(57. 5%) from the cholecystectomy group, but this difference was not statisticallysignificant. (P= 0. 175). Conclusion: Based on the results of this study, it can be said that chronic exposure and lead poisoning mayplay a role in the occurrence and change of gallstones and appendicitis.

Background and Objectives: vaginismus and Dyspareunia disorders is important issue in the field of painbecause this type of pain is part of emotional behaviors in marital relationships such as sexual intimacyand vaginal intercourse. The aim of the present study was to investigate the antecedents that lead to theexperience of vaginismus and Dyspareunia in women. Methods: This study was conducted with a qualitative approach and using the method of contractualcontent analysis with inductive method. 9 female participants with vaginismus and Dyspareunia wereselected by purposive sampling method and continued to saturate. After data collection, all interviewswere implemented and reviewed and the main components were extracted. First, the semantic unitswere identified and then turned into psychological expressions. Finally, the general structure was determinedand combined. Results: In general, thirteen predictive categories were identified using research data analysis. Accordingly, the preceding categories of this experience include incorrect family sex education, incorrect religiousattitude, sexual abuse, phobia, fatigue, lack or insufficiency of sexual awareness, sexual disorders of thespouse, psychological disorders of the spouse, fear of pregnancy, Lack of foreplay, suppression of sexualdesire, previous failed marriage and viewing pornographic images. Conclusion: The results of this study enrich the previous research literature on the antecedents of thelived experience of vaginismus and dyspareunia. Also, the structure of living experience of vaginismusand Dyspareunia extracted in this study is widely used to develop and implement prevention and treatmentprograms for this disorder.

Background and Objectives: Menstrual cycle may affect the training of strength and muscle size. The aim ofthe present study was to determine the effect of exercise volume distribution in the 2 follicular and lutealphases of the menstrual cycle on serum Insulin-like Growth Factor 1 (IGF-1) and muscle mass in women. Methods: in this semi experimental study’,20 amenorrheic women with a mean age of 22±, 5 years, withoutcontraceptive use and a history of eight weeks of resistance training were selected. Each subject had8 training sessions on one leg in the first 14 days of menstruation and 2 training sessions on the second14 days of menstruation (training in the follicular period) and the other leg had 2 training sessions on thefirst 14 days of menstruation and 8 training sessions on the second 14 days of menstruation (training inthe luteal period). The training protocol was consist of unilateral leg extension. Results: the quadriceps Muscle diameter (according to pretest size) in follicular training (FT) (0. 67±, 0. 34(cm)) was higher than luteal training(LT) (0. 46, 0. 41 cm) (P=0. 012). Also, insulin-like growth factor increasedin both groups (13%) regardless of the type of exercise schedule (P> 0. 001). Conclusion: According to this study it is recommended that follicular based training may cause more musclehypertrophy and maximum strength than luteal based training in young amenorrheic women whodo not take birth control pills.

Background and Objectives: Obesity and a sedentary lifestyle factors related to pulmonary function and cardiorespiratory requirements (CRF). This study was to determine the effect of regular aerobic training on cardiac and respiratory function in adolescent girls with different body mass index. Methods: In the present quasi-experiments (QEs) study, which was conducted with pre-test and post-test design, 45 female students in the age range of 13 to 18 years old were selected and added to 3 groups of 15 people with normal, overweight and obese body mass index. The training protocol included 10 weeks of aerobic training, 3 sessions per week and each exercise session for 20-45 minutes of. Pulmonary function was measured by spirogram and Maximal oxygen uptake (VO2max ) by modified treadmill bulk test. Results: There were significant differences in Forced Vital Capacity (FVC), Forced Expiration Volume in one Second (FEV1), Peak Expiratory Flow (PEF), FEV1/FVC and VO2max in groups with normal body mass index, overweight and obese (P<0. 001). After the training period, a significant improvement was observed in spirometry indices (FVC, FEV1, PEF, FEV1/VC) and VO2max compared to the pre-test (P <0. 001), but still significantly lower than the post-test values in the was normal group. Also significant decreased was observed in Body Mass Index (BMI) in obese and overweight groups (P<0. 001). Conclusion: The results of the present study showed that obesity is one of the effective factors in reducing pulmonary function and aerobic exercise improves pulmonary function and cardiorespiratory endurance in adolescent girls with different body mass index.

Background and Objectives: Depression during pregnancy is a common mental disorder that has manyside effects, including a disorder of the immune system. Recently, the available evidence supports theuse of aerobic exercise interventions in reducing depressive symptoms in mothers. The aim of this studywas to investigate the effect of an aerobic exercise period on levels of depression and Interleukin-6 (IL-6)concentration during pregnancy and postpartum in NMRI female mice. Methods: In this experimental and baseline study, 40 female NMRI mice with an approximate age of 80-90 days and a weight of 22-25 g were divided into four groups: Non Exercise in Pregnancy, Non Exercisein Postpartum, Exercise in Pregnancy, Exercise in Postpartum. After seeing the vaginal plaque and confirmingthe day of pregnancy of the animals, two running wheels were placed inside the cage of eachpregnant animal for aerobic activity. In order to induce depression during pregnancy and postpartum, pregnant mice from day 5 to 19 of pregnancy were exposed to stress for three sessions a day, and toassess depression levels, the rate of delay in access to food after 24 hours of food deprivation was measuredin seconds. At the end of the protocol, blood samples were taken from the heart to assess IL-6 andthe data were analyzed using one-way Analysis of variance (ANOVA). Results: According to the findings of this study, moderate and low intensity aerobic exercise duringpregnancy as well as in the postpartum period led to a significant decrease in levels of depression(P<0. 05) and concentration of IL-6 as an inflammatory cytokine in trained mice compared to sedentarymice (P<0. 05). Conclusion: This results of the present study showed, the aerobic activity used was able to reduce the levelsof depression and the concentration of inflammatory factor IL-6 during pregnancy and postpartum. Therefore, low-intensity aerobic activity can probably be used as a non-pharmacological interventionduring this period to reduce depressive symptoms and improve immune function.

Background and Objectives: One of the molecules that associated with cancer progression are Long non coding RNA (LncRNAs). HOX transcript antisense RNA (HOTAIR) is a member of the lncRNA family. Homeobox C13 (HOXC13) gene is one of the several HOX genes that is located near the HOTAIR. This study was to evaluate the expression of HOTAIR and HOXC13 genes in tumor and normal tissues adjacent to tumor in patients with esophageal cancer. Methods: This is an experimental study. 30 pairs of esophageal tumor tissue and tumor margin tissue were purchased. RNA of these tissues was extracted and Real-time PCR with Beta-actin gene was used for their relative expression. Statistical analysis of data, t-test and Analysis of variance (ANOVA) were performed in GraphPad Prism 8 software. Results: Comparison of target gene expression in esophageal tumor samples relative to tumor margins showed that the relative expression of the HOTAIR genes was 1. 95 time (P=0. 0219) and the HOXC13 14. 4 time (P=0. 014) significantly increased expression. Also, the HOXC13 gene expression shows a significant relationship with metastasis to distant regions, type and degree of tumor. The correlation coefficient between the relative expression of the HOTAIR and the HOXC13 genes was 0. 152. It was positive but not significant between the two genes (P=0. 2). Conclusion: A ccording to the association of the HOTAIR and the HOXC13 genes with cancer, our study may partially express the role of these two genes in the tumorigenesis process in the development of esophageal cancer.

Background and Objectives: Obesity is one of the factors associated with metabolic syndrome. The aim of the present study was to compare gross and fine motor skills, insulin resistance and lipid profile in normal, overweight and obese children. Methods: In the present study, 120 male and female students were randomly selected by cluster sampling and after final selection, they were divided into three groups of 40 people with normal weight, overweight and obese. The three groups were matched according to their year of birth and body mass index. In order the Bruininks-Oseretsky short form test was used to calculate the motor proficiency score. Biochemical variables were measured while fasting. Statistical analysis, factor analysis of variance and Bonferroni post hoc test were used at a significance level of P≤, 0. 05. Results: The results showed that significant decreases in gross and fine motor skills with increasing body mass index (P<0. 001). Insulin resistance was significantly higher in obese and overweight groups than normal weight groups (P<0. 001). Triglyceride levels were significantly higher in the obese group than the normal weight group (P=0. 013). Conclusion: According to the results, it can be said that in addition to reducing children's motor skills, increasing body weight causes parameters related to metabolic syndrome in children.