From the ancient time, the land of Iran, because of its geopolitical location, played an important role in terms of cultural interaction between the East and the West. Infact, one of the most attractive parts of the world history is cultural communication and also political conflicts between Iran, Greece and Roman Empires, as representatives of the East and the West. According to historical and archaeological evidences, it can be claimed that, among the craftsmen of both nations, there was a clear understanding on mythical and religious characters of other side. So, on the basis of iconographical studies, this paper aims to focus on two mythical characters, Tishtar and Pegasus, as a sign of cultural interaction, appeared on two Sassanid silverworks. This study, finally takes a result that how Iranian artisan in Sassanidera had imitated the form of Pegasus appearance on the Western art and used it as a prototype to show Tishtar on his works.