As Sharia, Narratives and human intellect provide, the right to life, as the most important of all human rights, cannot be denied or annihilated. Although under certain circumstances and in certain periods, war and defense appear inevitable, detailed evidence found in sharia and narratives as well as human intellect and the common soul of humanity, regardless of race, religion, etc.…, regard weapons of mass destruction and instances such as Hiroshima and Nagasaki as unforgivable violations of human and environmental rights. Such acts are forbidden in political, legal and moral teachings of Islam. This article seeks to prove the prohibition of production, multiplication, accumulation and use of weapons of mass destruction with a focus on existing rules based on the close association of human nature and Jurisprudence.