The usual t-test or F-test can not be used to analyze unreplicated two-level factorial designs, since all the observations are used to estimate the factor effects and no observation is left to estimate the error variance. To overcome this difficulty, various procedures have been proposed in the literature and several simulation studies have been carried out to compare the performance of these methods. The results of these studies have been inconclusive, and no test is widely accepted as a “best” test. In this paper, we present results that show theoretically that no test has high power against all possible alternatives; i.e. no test can detect all patterns of active effects. Therefore, in the absence of any prior information concerning active and inactive effects, no test can be preferred to any other test based on power and the choice of a test should be based on other considerations, such as ease of use, control of individual or experimental error rate, the purpose of the experiment, etc.