In this paper, it is tried to put a comparative analysis on the thought of Nietzsche and Iqbal Lahori in four bases of epistemology, ontology, methodology and purpose of anthropology. Nietzsche is in conflict with any of the first three, but inevitably signs of recognition can be found about the four abovementioned elements in his thoughts. Irrational epistemology, is based on the concept of atheism and nihilist; instinctive- methodology relies on intuition, instinct or intuition heaven-and anthropology naturalist relies on the concept of Nietzsche against love oriented epistemology, ontology integrated, hybrid methodology consisting of intellect, science and illumination and anthropological interest is love oriented. The main question here is: what are the Difference and similarity between Nietzsche and Iqbal in four vertices? They thought that the basic outline of the original claims, are largely different, but also overlap with each other. Understanding these basics is urgent to comprehend the political philosophy of the both thinkers.