Introduction: Annually, heavy metal pollution is increasing in the environment and this eventually causes serious hazards for health of human, animal and plant populations. Heavy metals with their harmful effects are the major pollutants in big cities. Tehran is a big city and faced with this problem. Heavy metals such as arsenic, iron, zinc, lead, cadmium, chromium, copper, manganese and nickel exist in the air of Tehran. These polluteants are inhaled by inhabitants and cause serious problems for human body. Among streets, roads and highways of the city, Enqelab Street is one of the busiest and particularly from Enqelab Square to Imam Hossein Square. In this study, the results of measuring heavy metals including arsenic, iron, zinc, lead, cadmium, chromium, copper, manganese and nickel in the air of the streetare presented with the health risk assessment from permanent and temporary residents in thearea. Moreover, the risk of developing cancer and non-cancer diseases caused by inhaling the polluted air with heavy metals was also estimated.