Prayer (Nam'az in Persian and/or Sal'at in Arabic), the spite of its beatific influence, consist of deep concept and mysteries. It has an irrefutable role as the firm line which attaches the human entity to the superfine heaven. In the Islam, prayer is the first act that has been necessitated and also a canonical duty for human which should be surely discharged by him until the last time of his live until the deathbed. Holy prophet (peace be upon him) has closely prescribed in many valuable anecdotes about the prayer and its important role on the corporal, spiritual and mental well-being. Just as a sample of this immeasurable ocean, he says: prayer is the light of my eye, my beloved and my favorite and in other sayings: it's essential for you all to mention the holy God that is the real cure.Moreover, there is so many religious orders and emphasis about the correct time of praying, its religious mandatory in field of ablution, prayer announcement (Aza'an), and also their hygienic influences on different aspects of human health. Anyways, prayer reforms the persons who pray and prohibit them against vice. As the less stated bounties of prayer, especially during modern civilization, it's definitive role on curing of body and spirit's diseases should be mentioned.Recent studies on this important matter have revealed significant statistical relations between prayer and it's positive impressions on the human's body system such as immune system (as increasing on some immune bioactive factors such as Interlukine-6), central nervous system (as reducing of depression's symptoms, anxiety and stress), gastrointestinal disorders (as preventing against common GI infections), skin tissue (as alleviating of chronic skin disorders), decreasing on the high blood pressure, improvement of sleep condition, and ...Finally, it should be mentioned that the presented articles by small- scale studies demonstrate so many applicable fields in the scientific researches and also professional titles in variable educational topics could be broadly designed. The authors have invincible belief that the opening of these new fields of researches demonstrate the unassailable worth and opulent potentials of the Islamic outlooks in medicine.