Objective: To compare two methods of treating the exuberant granulation tissue with scalpel (sharp debridement) and curettage (blunt debridement) alone and with non adhesive - bandage.Design: Interventional study, 4x4 Latin square. Animals: Lateral aspect of metacarpal or metatarsal region of each limb of four healthy adult horses.Procedure: Creation of a 50 cm2 (5x 10) full-thickness wounds, formation of the exuberant granulation tissue within 35 days by tap-water and 10% solution of providence-iodine. Four groups of treatment such as: A) Curettage, B) Scalpel, C) Curettage with non-adhesive bandage, D) Scalpel with no adhesive bandage was applied respectively.Statistical analysis: Slope of linear regression, Analysis of Covariance. Results: The wounds of group D were healed completely during 42 days. Other wounds had unhealed area 42 days after the commencement of treatment, except two wounds of group C. The best cosmetic appearance was observed in group D. The wounds were treated with scalpel healed significantly faster than wounds were treated by curettage. Also healing rate in groups C and D was significantly faster than groups A and B.Clinical implications: From the results of this study it seems that sharp debridement with non-adhesive bandage for treating exuberant granulation tissue of lower limb open wounds in horses could be recommended.