N, N-3, 4-di(methylamino)-1, 2, 5-oxadiazole (lf) was prepared by dehydration of N, N-3, 4-di(methylamino) glyoxime (2f) in aqueous potassium hydroxid at 170-180 °C. Under similar conditions N N-3, 4-di (benzylamino)-1, 2, 5-oxadiazole (1c) arid N, N-3, 4di (isopropylamino)-1, 2, 5-oxadiazole (1e) were not obtained, but, N, N-3, 4-di (ethylamino)-1, 2, 5oxadiazole (1g) was appeared with small amount.