مجله علمی پژوهشی دانشگاه علوم پزشکی شهید صدوقی یزد
سال:1395 | دوره:24 | شماره:5 |تعداد مقالات:10

Introduction: After cardiovascular disease and cancer, stroke is the third most common cause of death in the most industrialized countries. The aim of study was assessment of relationship between the effect of Boswelliaserrata aqueous extracts infarct volume in rat stroke model.Methods: Five groups, each consisting of 7 male wistar rats, were studied. The groups consisting of control, sham and three treatment groups received aqueous extracts Boswelliaserrata for 30 days (50, 100 and 150mg/kg day, respectively). The control group received distilled water, while in ischemia induction and sham group they did not receive distrill water. Two hours after the last gavaged dose, overly group with 7 pieces operated for measurement of amount of infarct volume and neurologic deficits. (Middle Cerebral Artery Occlusion Model). The data were analyzed via ANOVA test.Results: In comparison to the ischemia group, pre- treatment aqueous extracts Boswelliaserrata with the doses of 100 and 150 mg/kg body weight indicated a meaningful difference. In addition, median score of neurological violation was significantly reduced through aqueous extracts Boswelliaserrata consumption in the doses of 100 and 150 mg/kg body weight, compared to the ischemia group.Conclusion:According to this study, aqueous extracts of Boswelliaserrata can reduce the amount of tissue damage caused by stroke and neurological protection.

Introduction: Epilepsy is the most common disorder of the central nerves system. Patients suffering from epilepsy can experience a wide range of neuropsychological disorders such as impaired memory, disturbances in attention and information processing. Due to the effect of anticonvulsant carbamazepine and its effect on the memory and learning, the aim of this study was investigating the effect of Carbamazepine on passive avoidance learning in male rats seizure model.Methods: 30 male Wistar rats with an average weight of 230±20 g were used in the study. Animals were randomly divided into 5 groups. Seizure was induced by administration of pentylenetetrazole (PTZ: 60 mg/kg, ip). After induction of seizure the learning and memory of rats was tested in shuttle box. Latency to enter the dark room memory was evaluated as indicators of learning and memory. The data were analyzed by one way variance analysis and Tukey’s test using SPSS.Results: Pentylenetetrazole-induced seizures (PTZ) in acquisition group significantly reduced the latency to enter the dark room (P<0.01). Carbamazepine significantly reduce the entrance time in intact rats and kindled rats by PTZ (P<0.05, P<0.01).Conclusion: This study showed that the administration of Carbamazepine in seizure rats can cause the increasing learning and memory impairments in rats by Pentylenetetrazole.