Hydrogeochemistry has been used in recent years as a successful exploration drilling for sedimentary deposits, with a particular interest for the uranium. Like any other exploration activity, hydrogeochemistry needs to identify and investigate the region, especially the hydrogeological one. Ferdows region is one of the priority areas for uranium exploration, where the identification and exploration activities in the prospecting phase have begun since 1388. Because of the detection of uranium mineralization in the area and existence of sedimental uranium mineralization conditions, the hydrogeochemical exploration activities in the area is on the agenda. In this respect, 19 water samples by standard methods were taken and after analysis of metals, carbonates and ions processing and interpretation of results indicated that uranium transfer capability in the region was is extremely limited and the probability of mineralization is low. However, due to high levels of uranium tracers in these areas, the possibility of vein type mineralization of uranium in the upstream is existing and needs to be investigated further.