Background and Objective Considered the most important organizational capital, human resources productivity can improve organizational productivity and excellence. This study aimed to identify the factors affecting human resources productivity in scientific and technological organizations of the selected countries (Germany, England, Turkey, Taiwan, and South Korea) and evaluate the identified components in the Academic Center for Education, Culture and Research of Iran. Methodology A comparative research approach was first used along with the experiences of scientific and technological organizations of the selected countries to identify and evaluate the most important constituent components of human resources productivity. The structural equation modeling (SEM) technique was then employed to analyze the relationships between the identified components. The statistical population included the experienced managers and deputies of the Academic Center for Education, Culture and Research of Iran, 57 of whom were selected and surveyed through the purposive sampling method in this applied-descriptive survey. Findings Organizational support, education, organizational culture, job satisfaction, employee motivation, organizational structure, efficient and effective leadership and management, competitiveness, creativity, and innovation were identified as important and effective components of human resources productivity in scientific and technological organizations. Conclusion Managers of scientific and technological organizations can enhance organizational productivity by improving, modifying, and change the abovementioned factors. They can also achieve their organizational goals properly to meet their needs and accomplish their important missions.