Introduction: Academic Adjustment is one of the important also, effective factors on academic performance, and in this regards, studies have been conducted in schools and universities. The present research has been done to investigate The Role of Self-Construal and Academic emotions in predicting Academic Adjustment of medical student's. Methods: This is a descriptive/correlation research. Population of this study included all students who were studying in Alborz University of Medical Sciences in academic year of 2017-2018 that 395 students were selected by multi-stage random sampling method. For gathering data, Selfconstrual questionnaire of Hardin, Leong & Bhagwat, and Academic Emotions Questionnaire of Pekrun, Goetz & Frenzel, adjustment questionnaire of Baker and Siryk were used. Collected data were analyzed by using Pearson correlation test and step-by-step multiple regression method in SPSS. Results: Results suggested that there is positive and significant relationship between dependent Self-Construal (P<0. 01, r=0. 20) and positive Academic emotion with academic adjustment (P<0. 01, r=0. 16). also, negative and significant relationship between Independent self construal (P<0. 05, r=-0. 11) and negative Academic emotion with academic adjustment (P<0. 05, r=-0. 13). Results of step-by-step multiple regressions indicated that dependent Self-Construal and positive Academic emotion could positively and significantly predict students' academic adjustment. Conclusion: According to the results of this study, dependent Self-Construal and positive Academic emotion play a significant role in the prediction of students' academic adjustment. So, it is recommended that students’ counseling centers in universities holding educational workshops which focus on Self-Construal and Academic emotion by the aim of increasing academic adjustment in students.