Introduction: Various symptoms have been attributed to tooth eruption. Further, parents use different strategies to reduce or eliminate these symptoms. This study was aimed to evaluate parental information about eruption of primary teeth in Isfahan, Iran. Materials & Methods: This descriptive, cross-sectional survey was conducted on 100 parents having sixmonth-to three-year-old children referring to the dental clinics or offices in Isfahan. A questionnaire with validated face and content validity was designed to collect data. It included questions about demographic characteristics, eruption time and the first erupted tooth, symptoms of eruption, and control of symptoms. Data were analyzed by frequency distribution, relative frequency, descriptive indices, and chi-square test via SPSS 22. 0. p value < 0. 05 was considered to be statistically significant. Results: The most frequent symptoms parents agreed with included high tendency to bite and chew, high saliva flow, and gingival inflammation, respectively. Fever was the most frequent symptom the majority of parents disagreed with. The most frequent methods used by the parents included hugging the child and amusing the child. The most frequent disagreement was reported for the use of sleeping drugs. No significant correlation between parental information about tooth eruption and economic status, parental education, parental age, and number of children was found. (p value < 0. 05) The mean score of parental information was 2. 37 ± 0. 97 and degree of response was 96%. Conclusion: Parents’ knowledge about tooth eruption was moderate and acceptable awareness on symptoms of tooth eruption and methods of decreasing the symptoms was found.