Tourism industry affects comprehensive development including the economic development. Therefore, using futures studies are an appropriate tool for predicting the future of tourism and hence the orientation of management practices at the present time. This study was conducted to find drivers of development of natural and cultural tourism by descriptive-analytical method in Sistan region. For this purpose, 100 drivers were identified as barriers to tourism development in the region using the fieldwork, literature review, and brainstorming. Subsequently, drivers were classified in five domains and, if necessary, corrected or merged. The most important drivers were selected using Delphi method which contains 55 variables in the infrastructural, political, institutional, social and natural domains. These variables were screened using Structural Analysis to get influential drivers with high influence and low dependence capacity. The state of the dispersion of variables in the dependence and influence axes showed that the system is stable in both direct and indirect methods of Structural Analysis. The political factor followed by the institutional factor with six and four variables in the direct method and five and two variables in the indirect method were identified as the most important factors in the undeveloped tourism industry in Sistan, respectively. Among the influential drivers, weak planning, lack of long-term planning, and lack of integrated management include 6. 16, 5. 98, and 5. 36 percent of total values respectively; and they were identified as the most influence drivers. The lack of investment in the region has also been identified as a key dependent driver to assess the tourism status in Sistan.