Introduction & Objective: Inguinal hernia repair is one of the most common surgeries in general surgery field. Lichtenstein Hernioplasty is the most popular method for this repair. Inguinal hernia repair is a clean operation but because of using mesh (a prosthetic device), prophylactic antibiotic is routinely used to reduce the incidence of wound infection. The aim of this study is the evaluation of the role of prophylactic antibiotic in the prevention of wound infection in patients undergoing elective mesh repair of inguinal hernia.Materials & Methods: This is an interventional study in which 270 patients (15-50 yr) who underwent elective inguinal hernia repair with Lichten Stein method at Shahid Beheshti Hospital in Kashan were selected. 135 of patient (50%) s received 1g intravenous Cefazolin, 30 minutes before the operation while 135 patients (50%) did not receive any antibiotic prophylaxis. In the 7th and 30th days after the operation, patients were followed up to investigate the wound infection rate. For analyzing of quantitative variables we used mean, standard deviation, t-test and for qualitative variables chi square test was applied.Results: In both groups, no wound infection was observed (neither superficial nor deep) in the patients, after one week and one month of the operation.Conclusions: The application of the prophylactic antibiotic in a routine manner and particularly in low risk patients operated on for elective hernioplasty with mesh is not recommended. Different studies showed no general agreement on this subject. Hence, further studies with larger sample size, in this field is recommended.