Iranian Journal of Diabetes and Metabolism
Year:2020 | Volume:19 | Issue:6|Papers Count:6

Background: Over the past half-century, the prevalence of obesity and related metabolic disorders such as fat disorders, cardiovascular disease, myocardial infarction and stroke have increased dramatically. Various types of organisms, including bacteria, fungi, protozoan, and viruses, have evolved to live in the human gut, called microbiota. Scientists have found that thin people have a balanced microbiota in their gut that causes them to lose weight, so they use a method called fecal grafting and fecal capsules to treat obesity. The aim of this study is to introduce fecal graft and its capsule in the treatment of drug-resistant obesity. Methods: This article is a systematic review of the study which English and Persian articles are obtained from regular search of Internet resources using logical AND, OR function between keywords in Pub Med, Google scholar databases using English keywords, FMT, obesity, poop capsule, weight loss has been done from 2010-2020. The total search for fecal transplant related resources was 474 articles. Then, by applying the time filter, this number was reduced to 237 articles. In the final stage, by eliminating duplicate articles and examining the relationship of articles with the subject under study, 23 articles were selected as relevant and final sources. Results: In the treatment of obesity with FMT, the donor's stool is transferred to the recipient after screening and necessary tests using various methods such as enema or colonoscopy, and then the recipient gradually loses weight by receiving a balanced microbiota of the donor. Instead of a stool transplant, which is a relatively invasive procedure, stool capsules consisting of the donor's dried stool can be used. Conclusions: Stool transplantation and fecal capsule are an effective method in weight loss of obese people (BMI> 30) with due consideration. Due to the novelty of the treatment method, further studies in this field, especially clinical studies of this method in the treatment of obese people in the country are also recommended.

Background: The pathway of insulin messengers is so important that diabetes can lead to disruption of this pathway. However, the aim of this study was to investigate the effect of 8 weeks of endurance training on protein Kinase-B (PKB or AKT) and mechanical target of rapamycin (mTOR) in the left ventricle of the heart of diabetic rats induced by streptozotocin and nicotinamide. Methods: In this experimental study, 12 head two-month-old Sprague-Dawley rats with a mean weight of 270± 20 g were selected. After diabetic induction with streptozotocin and Nicotinamide, rats were randomly assigned to two groups, training and control (6 heads in group each). The rat training program was performed on a treadmill for 8 weeks and 4 sessions per week, including 30 minutes of endurance training with an intensity of about 50 to 70% of the maximum speed. SPSS software and independent t-test were used to analyze the data. Results: Eight weeks of endurance training resulted in a significant increase in protein Kinase-B content (P=0. 03); But no significant change in Protein Mechanistic Target of Rapamycin content was observed in the endurance training group compared to the control (P=0. 97). Conclusion: protein Kinase-B is a key protein for regulating many cellular pathways, which was significantly increased by eight weeks of endurance training. Due to the fact that the content of protein mechanistic target of rapamycin does not change, it is possible that endurance training cannot lead to physiological hypertrophy heart through the mTORC1 pathway.

Background: The role of Wnts as mediators of pancreatic development has been confirmed, and exercise training may affect this process. Therefore, the present study aimed to investigate the effect of eight weeks of resistance training and moderate-intensity training on plasma Wnt3a, Wnt4, and pancreatic beta-cell count in streptozotocin-induced diabetic rats. Methods: Twenty-four rats were divided into four groups: healthy control, diabetic control, diabetic + moderate-intensity continuous training, and diabetic + moderate-intensity resistance training. Diabetes was induced by intravenous injection of 110 mg nicotinamide and 40 mg streptozotocin per kg of body weight. The exercise training intervention was performed for eight weeks. Plasma Wnt3a and Wnt4 were measured by the ELISA method, and the number of beta cells was assessed by hematoxylin-eosin. Results: Data analysis showed that the number of beta cells in the exercise group increased significantly compared to the diabetic control group (P<0. 05). Also, a significant change was observed in the plasma levels of Wnt3a and Wnt4 in the exercise group compared to the healthy control group (P<0. 05). Conclusion: It seems that eight weeks of moderate-intensity continuous training and eight weeks of moderate-intensity resistance training probably caused the proliferation and protection of beta cells in response to an increase in Wnt3a and a decrease in Wnt4 in the diabetic rats.

Background: Obesity and type 2 diabetes can impair the function of cells, including CREB and CRTC2 proteins, which are important for regulating adipose tissue metabolism. Therefore, the purpose of the present study was to investigate the effect of eight weeks of high intensity interval training (HIIT) on CREB and CRTC2 proteins levels in subcutaneous adipose tissue of obese rats with type 2 diabetes. Methods: In this experimental study, 12 head two-month-old Sprague-Dawley rats with a mean weight of 300± 20 g were selected. After diabetic induction with Streptozotocin and Nicotinamide, rats were randomly assigned to two groups, diabetic training (6 heads) and diabetic control (6 heads). The training groups performed the training program 4 days a week for 8 weeks, including 5 interval 4-minute with an intensity of 85 to 95% of the maximum speed, and 3-minute active rest periods with an intensity of 50 to 60% of the maximum speed; SPSS software version 23 and independent t-test were used to analyze the data. Result: After eight weeks of HIIT training, no significant change in CREB protein level was observed in the training group compared to the control (P<0. 22); However, a significant increase in CRTC2 protein level was observed in the training group compared to the control (P<0. 005); Conclusion: HIIT training did not result in a change in CREB protein level. But, it was able to increase the CRTC2 protein level, which could lead to the regulation of adipose tissue metabolism in diabetic subjects.

Background: The purpose of this study was to evaluate the effect of six weeks of endurance training with sour lemon consumption on plasma levels of endolin-1 and nitric oxide in streptozotocin-induced diabetic rats. Methods: In this experimental study, 72 male Wistar rats (Weight; 200 ± 12 g) were selected and randomly divided into eight groups after becoming diabetic. Endurance training protocol was performed on rats for 6 weeks. Lemon essential oil (50 mg/kg) was administered using gavage. Plasma endolin-1 levels were measured by ELISA and serum nitrite levels were measured as a major metabolite of nitric oxide. One-way analysis of variance and Tukey's post hoc test were used for statistical analysis. Results: The results showed that the mean levels of endothelin-1 in the endurance training + lemon group and diabetes + endurance training + lemon were significantly lower than the control group (p<0. 05). Also, the mean nitric oxide levels in the diabetes + lemon group were significantly lower compared to the control group, but in the endurance + lemon training group and the diabetes + endurance training + lemon group was significantly higher than the control group (p<0. 05). Conclusion: According to the results of this study, it can be concluded that endurance training with consumption of lemon may improve endothelial function and vascular occlusion in diabetic patients by reducing the concentration of endothelin-1 levels and increasing nitric oxide levels.

Background: Assessing the health literacy of diabetic patients requires the availability of a tool specific to this group. The Diabetes Health Literacy Assessment Questionnaire (LAD) is one of the tools used to measure the health literacy of diabetic patients. The present study was conducted with the aim of translating and validating the Persian version of the LAD questionnaire. Methods: The present study aimed to determine the validity and reliability of the Persian version of the Health Literacy Assessment Questionnaire for diabetic patients on 300 patients with diabetes in 1398, by sampling. Stages of study: First: Translation and preparation of the Persian version of the health literacy questionnaire in order to design and select items and their qualitative evaluation by the second group: Quantitative evaluation of narrative features using the opinions of the third group of experts: Formal narrative evaluation (comprehensibility) and The reliability of the questionnaire was assessed by a small group of the target population in a fourth experimental study: analysis of items, validity assessment and reliability of the final questionnaire. Results: In the analysis of organizational structure items, the effects of roof and floor were not observed. The highest averages were for items 8 and 12 and the lowest averages were for items 6. According to the Skewness Index, no deviation was observed in the items. Based on the results, the instrument had acceptable internal stability. Detective factor analysis identified two factors for the Diabetes Health Literacy Questionnaire: one was individual understanding and the second was social support. Conclusion: The results of exploratory factor analysis, Diabetes Health Literacy Questionnaire (LAD) have good validity and reliability and can be used to measure the health literacy of diabetic patients.