Journal of Isfahan Medical School
Year:2014 | Volume:32 | Issue:295|Papers Count:8

Background: Increase in human aging years due to remarkable and progressive expansion of medical science and technology has got the humanity to special attention and attitude toward the elderly who have a plausible role in this progression. So medical care’s related to elderly is great importance. Surly the process of diagnosis, rehabilitation another effect related to elderly confront its difficulties and demands special care. According to the united nation report in 2000, there are about 590 million elderly people that this number exceeds 1 billion and 100 million. Currently in the developmental countries elderly population count is 25%. In Iran 4% of population age more than 65 years old that this number is similar to developed country. Due to the most common disease that ensuring hospitalization in elderly, with future educational and treatment plans. The aim of this study was to evaluate causes of the greatest hospitals of Isfahan province.Methods: This cross-sectional study was done in Alzahra hospital at 2011.All elderly patient older than65 who referred to this hospital included in this study. Age, sex, chief complain, admitted service and duration of admission were recorded. Data were analyzed by SPSS 13.5 statistical software. P value less than 0.05 consider as significant level.Findings: The most common chief complain were gastrointestinal disorder and dyspnea respectively. Electric shock, sore throat, anaphylaxis shock and hemoptysis were less common.Conclusion: According to high prevalence of referral elderly patient to this hospital. Increasing of elderly population in future year and shifting the disease to this patient, we concluded that necessary percussion should be considered.

Background: The wet cutaneus leishmaniasis caused by Leis hmania major infection is one of the common skin disease in many parts of the world. Reports indicate that some properties of Leis hmania such as time of infection is affected of medium. With respect to use to artificial medium in the majority of the studies on Leismania and the role of acid phosphatase in the pathogenesis of promastigotes, in this research, were studied effects of medium in properties of ACP and time of infecting in L.major promastigotes.Methods: The present study is a cross sectional study. To culture promastigotes, L.major (MRHO/IR/75/ER) from previously infected Balb/c mice was transferred to NNN and RPMI1640 medium. Growth curve was generated and stationary stages were divided. Frozen promastigotes of each medium with sodium acetate and Triton-X-100 were homogenize and ACP was measured by calorimetric assay.Findings: Stationary parasites were collected in NNN and RPMI-1640 medium in seventh and fifth day respectively. The rate of ACP activity was determined, 1.02±0.08 in NNN and 1.8±0.01 in RPMI- 1640. Also Km and Vmax of this enzyme was 105.26±1.11 mM and 98.37±1.48 mM/min/mg protein in NNN and 106.39±1.14 mM and 98.04±0.96 mM/min/mg protein in RPMI1640.Conclusion: Despite the infecting time in promastigotes, rate of agglutination, rate of kinase synthesis and virulent are different in two medium, it seems there are no significant differences in properties of acid phosphatase in stationary promastigotes in two medium.

Background: Chronic pain is one of the most current multi-dimensional problems which that’s management requires medical and psychological interventions. This study aims to evaluate the effectiveness of group-based acceptance and commitment therapy on pain-related anxiety, acceptance of pain d pain intensity in Patients with Chronic Pain.Methods: with randomized clinical trial method 30patients met entry criteria were selected from medical centers affiliated with Isfahan Medical University, using purposive sampling and divided randomly into two groups. Research instruments were Chronic Pain Acceptance Questionnaire (CPAQ), Short Form of Pain-Related Anxiety Symptoms Scale (PASS-20), Pain Intensity Scale (PIS) and a demographic questionnaire. Experimental group were treated with acceptance and commitment therapy during the 8-session group 1.5 h. Follow up was two months after the last treatment session.Findings: Acceptance and commitment therapy showed a reduction in pain related anxiety and pain intensity and increase of acceptance of pain (P<0.05).Conclusion: Findings indicates on effectiveness of this new behavioral therapy which is probably more appropriate for Iranian patients because of integrating behavioral therapy methods with eastern treatment techniques.

Bacteria of the genus Brucella are intracellular pathogens capable of surviving and replicating within macrophages of mammalian hosts. Resistance to killing in professional phagocytic cells controls survival and chronic infection. Recent advances have shed light on virulence factors and host functions involved at various stages of the Brucella intracellular life cycle. This review focuses on how this pathogen uses multiple strategies to circumvent macrophage defense mechanisms and generate an organelle permissive for replication. In addition, we discuss about host immune responses to Brucella and new strategies are used to produce an efficient vaccine against Brucella infection.

Background: Acinetobacter baumannii is one of the most important pathogen in hospital acquired infections especially in intensive care units (ICUs). This opportunistic pathogen can be easily isolated from water, soil, and hospital facilities. A.baumannii as a nosocomial opportunistic pathogen is resistant to wide range of antibiotics. The aim of this study was to determine frequency and resistance patterns of A.baumannii isolated ICUs of Isfahan Hospitals.Methods: During one year period (2012-2013), 350 specimens were collected from ICUs of Isfahan hospitals. The specimens were characterized as A .baumannii by conventional phenotypic and biochemical tests.The isolates were confirmed by PCR for OXA_51 like gene. Susceptibility of isolates was determined by standard disk diffusion method according to CLSI.Findings: From 350 specimens, 43 isolates was Acinetobacter baumannii .The antimicrobial patterns of isolates showed that 53.5% of isolates were resistant to amikacin, 83.7% to tetracyclin, 86% to ceftazidime, 90.7% to trimetoprim sulfametoxazol, 93% to imipenem, cefepime, meropenem, ampicillin -Sulbactam. All isolates were resistant to ciprofloxacin. Our findings showed that all of Acinetobacter, isolated from the ICU of Isfahan hospitals were MDR.Conclusion: This study showed a high resistant of A.baumannii to a wide range of antimicrobial agent. It is necessary to adopt appropriate strategies to control the spread of the bacteria in care unit centers and wards.