Iranian Journal of Diabetes and Metabolism
Year:2017 | Volume:17 | Issue:1 |Papers Count:7

Background: Diabetes is one of the most common diseases of the body's endocrine system, Based on present forecasts of its prevalence will increase in human societies. Diabetes mellitus consists of 5 groups, its two major groups: type I diabetes or insulin-dependent and type II diabetes or non-insulin dependent diabetes. The aim of this study was to evaluate the effect of alcoholic extract of green wheat leaves on glucose, cholesterol, triglycerides, LDL, HDL and total antioxidant capacity of blood serum in alloxan-induced diabetic mice.Methods: In this study, 40 male mice with an average weight of 25-20 grams in eight groups of five rats: The negative control, positive control (sham), Methformin (60mg/kg), green Wheat leaf extract (100, 200, 400, 800 and 1000mg/kg) were tested. Blood glucose was measured at baseline, then in the positive control group and the experimental groups by Alloxan (120mg/kg) Diabetes was induced by intraperitoneally. During the study, the positive control group and experimental groups received aforementioned compounds for 10 days via intraperitoneally and after 48 hours of each group blood samples were taken through the intraventricular anesthesia and glucose, cholesterol, triglycerides, LDL, HDL and total antioxidant capacity in serum were measured. Quantitative results achieved in this research by one-way ANOVA and Tukey post hoc test between the groups studied Considering the significance level of p<% 5 were analyzed.Results: The results showed that blood glucose changes in green Wheat leaf extract and metformin groups compared with the positive control group and negative control group was significant at the 5% level and In all under study groups blood glucose levels, Compared with the positive control group decreased and is close to the negative control group also in doses of 100, 200, 800 and 1000 mg/kg Reduced blood glucose is better than methformin group. Methformin and green Wheat leaf extract caused a significant increase at all doses studied in the TAC's Blood. Methformin and green Wheat leaf extract on the amounts of LDL, HDL and cholesterol in diabetic groups had no significant effect and did not have significant difference with other groups. There was no significant effect of different doses of green Wheat leaf extract on the blood triglycerides. However, metformin has a significant impact on triglyceride levels.Conclusion: The results of the effects of green Wheat leaf extract on glucose and serum antioxidant capacity It can be noted that these extracts in the treatment of diabetes and reduce its complications can be considered as an option.

Background: Adherence to diet is one of the basis of diabetes management in patients with diabetes. Regarding to diabetes control, healthy lifestyle including nutritional behaviors, play an important role in preventing and managing diabetes. However, compliance with a diabetic diet is one of the most important challenges in diabetes control. This study aimed at determining the effect of educational intervention on promoting nutrition adherence among patients with type 2 diabetes referee to south health center of Tehran University of Medical Sciences based on Health Belief Model.Methods: This interventional study was performed with216 type 2 diabetes patients as population study who referred to health centers in south of Tehran. Participants were randomly allocated to intervention and control groups. Questionnaires were completed by both groups at baseline, three and six months after intervention. Intervention group received intervention including during the month, six training sessions for 45 to 60 minutes for group training and Q & A With the package held at meetings to assess the diabetes-related complications. SPSS software version 22 utilized to data analysis using t-test and repeated measure analysis. Significance level was set less than 0.05.Results: Before the intervention, demographics and HBM constructs model were not significantly different in two groups. In intervention group, there were statistically significant differences between all parts of HBM after educational intervention (perceived susceptibility (p<0.001), perceived severity (p<0.001), perceived benefits (p<0.001), perceived barriers (p<0.001), cues to action (p<0.001)), also nutrition adherence (p<0.001) and HbA1c. there was no significant differences in control group after intervention.Conclusion: According to study results, it can be concluded that education through Health Belief Model can be effective to follow in terms of improved nutrition among patients with type 2 diabetes.

Background: Gestational diabetes in on of common complications of pregnancy which has different complications for fetus and mother. Aim of present study was to review the effect of six weeks aqua training in second trimester of pregnancy on visfatin and glucose tolerance of gestational diabetic women.Methods: In this semi experimental research 24 gestational diabetic mothers who recourse to hafez clinic of shiraz city which were in 23- 24 week of pregnancy select as sample and divided in two groups of 12 persons of aqua training and control. Aqua training group trained aqua trainings 6 weeks, 3 sessions per week and 45 minutes per session. In this period of the time control group has just their daily activities. For measure the research variables fasting blood sample gathered from antecubital vein in pretest and posttest.Results: Six weeks aqua training in second trimester of pregnancy has significant effect on increase of visfatin and decrease of glucose tolerance of gestational diabetic women (p=0.001).Conclusion: It seems that for improvement of visfatin levels and glucose tolerance of gestational diabetic women can use six weeks aqua training in second trimester of pregnancy.

Background: The diabetes is one of the most common chronic diseases in the world. One of the most considerable factor in case of a diabetic patient is quality of life. and the home visit can be effective. The present study aims to investigate the effects of home visits on quality of life type II diabetes.Methods: the present study is a clinical trial study for which 61 patients suffering type II diabetes visiting healthcare homes in the villages in Maragheh, were selected considering the criteria for entering the study and using random sampling method. Later on, in order to control the limitations, subjects were homogenized according to their age, marital status, education and the period of their illness. Then, they were divided into two control and experimental groups. then all units of study completed Quality of life questionnair before and after the intervention (6 month structured program of home visits). Data were analysed by SPSS and descriptive and analytic stastics (t test) Results: The finding showed there was a significant difference between mean Quality of life in case group befor and after the intervention (P<0.01). But there was no significant between mean Quality of life in control group befor and after the intervention (P>0.05).Conclusion: Based on the finding of this study, home visit has been effective on the improvement of Quality of life, and the nurses by appropriate intervention and home visit can help to improve quality of life.

Background: visfatin secreted by various factors, including cytokines such as TNF-a and IL-6 is affected. The purpose of this study was to evaluate the effect of eight weeks of combined training (resistance circular - aerobic) visfatin concentration, IL-6 and TNF-a in obese men with type II diabetes.Methods: The population of the research was all men with diabetes type II in District 2 of Ahwaz. Twenty four patients with diabetes type II, aged 40-55 years and fasting blood glucose lower than 200 mg /dl were selected by purposive sampling. First, the anthropometric variables and body composition were measured, then subjects were randomly divided into two groups (experimental, n=12 and control, n=12). Combined exercise training was done for 8 weeks (5 days/week, 30 to 50 minutes) for experimental group. To analyze the changes in the covariance analysis and dependent t test measured variables at a significance level of p£05.Result: After eight-week combined exercise training, fasting blood glucose and plasma visfatin significantly decreased p≤05. But no significant changes were observed in the levels of IL-6 and TNF-a p³5. Also, the inverse relationship between plasma visfatin with IL-6 and TNF-a was observed (P£0.05).Conclusion: Eight weeks of combined training despite a positive effect on plasma visfatin, due to no significant changes in plasma IL-6 and TNF-a in patients with type 2 diabetes, it seems this type of exercise in reducing obesity and visceral fat and thereby reducing plasma visfatin is appropriate, but the potential change in IL-6 and TNF-a does.

Background: Type 2 diabetes is the most common type of diabetes, and a complex endocrine metabolic disorder that one of its main complications is diabetic foot ulcers. Matrix metalloproteinases (MMPs) are one of the key enzymes in the reconstruction of extracellular matrix which have proteolytic activity. The aim of this research is based on evaluating relationship between -1562 C>T allele at MMP-9 gene promoter with diabetic foot ulcer in type II diabetic patients. If such correlation proves, it can be used as a prognostic biomarker in patients with high-risk.Methods: This is a case-control study. The single nucleotide polymorphism of -1562C>T allele of MMP9 gene promoter was genotyped by hit Tetra ARMS PCR technique in 100 diabetic patients with foot ulcer grade 1 or 2 as the case group according Wagne r classification and in 100 diabetic patients without foot ulcer as the control group.Results: The Chi-square test revealed significant difference in genotype frequency of CC, CT and TT alleles of -1562C>T allele of MMP9 gene promoter between case and control groups (P=0.000).Conclusion: According to this study, there is a relationship between -1562C>T allele of MMP9 gene promoter with diabetic foot ulcer in type2 diabetes patients. Thus we can introduce this biomarker for evaluation of risk and prognosis of diabetic foot ulcers.