Insulin dependent diabetes is the most common of the metabolic abnormalities, the long term complications involve the eyes, kidneys, nerves, blood vessels by the lesion of basement membranes. Patients fulfilling these criteria are not a hemogenous group, and several distinct diabetic syndromes have been delineated, such as alveolar bone resoption and delay bone formation. Increasing clinical use of demineralized bone matrix (DBM) has brought the desire to understand the osteoinductivity of this material. In this study we selected four groups male rat (w=240-200 gr, N-5per group) as follow; first group; as control, second, third, fourth group; diabetic (three later groups by use of alloxan 5.2 mg/kg diabete induced) only group 4 treated with Insulin (NPH unit daily) after 10 day upper right Incisor tooth extracted by with adapted Instrument. In group 3 and 4 tried to fill soket with DBM. At the end of first, second, 3 the a the week animals sacrified. Specimens were prepared and stained with H, E. Pictures were taken from histological sections.Results showed in group 4 bone repair occurred better than groups it seems that DBM is a osteoinductive material to stimulate cells to become osteoblasts and produce bone matrix.