Forged and heat treated low alloy steels containing Ni, Cr, Mo, V have a wide applications in industry. In such steels, the amounts of Mn and Cu have a great influence on the mechanical properties. The effects of Cu and Mn on the mechanical properties of a low alloy steel containing Ni, Cr, Mo, V have been investigated in the present research. The specimens with different amounts of Cu, Mn in the range of, 0.15, .0.45, 0.23-0.85 were used, respectively. The specimens were austenitized and quenched after forging. Tension test, impact test and hardness measurements were carried out to investigate the effects of Cu and Mn on the mechanical properties. Fractography and microstructural evaluation have been carried out by optical microscopy and SEM. The results showed that increasing the amount of Cu, improve the hardness, as well as the yield and ultimate tensile strengths and reduce the ductility. The impact energy showed a maximum value at %0.25 Cu. However, by increasing the amount of Cu to %0.45, the impact energy is reduced. Increasing the amount of Mn from %0.35 to %0.85, leads to improvement in hardness, as well as yield and ultimate tensile strengths. The impact energy showed a maximum value with %0.35 Mn, but with increasing the amount of Mn to %0.85, the impact energy is reduced due to increase in MnS inclusions.A significant change is not observed by increasing the amount of Cu and Mn. According to the results of mechanical properties, the best combination of strength and toughness are found with the amount of %0.25 Cu in steel containing Cu and %0.35 Mn in steel containing Mn.