In this research, the effects of three variables, soymilk concentration (0-25%), CaCl2 (0.3-1%) and coagulation temperature (30- 40oC) on sensory (taste, texture) and chemical (amount of total solids, protein and fat) properties of UF Feta cheese made from cow's milk and soymilk blend were investigated. The central composite experimental design (CCD) was used and the data were analyzed using response surface methodology (RSM). Coefficients of determination, R2, of fitted regression models for taste, texture, total solids, protein content and fat content were 0.965, 0.918, 0.924, 0.999 and 0.841, respectively. The Result of analysis of variance (ANOVA) table showed that lack of fit was not significant for all response surface models at 95%. Therefore, the models for all response variables were highly adequate. The results showed that the optimum processing conditions for producing cheese with highest overall values for response variables were 15% soymilk, 0.3% CaCl2 and coagulation temperature of 38oC. The response values for such product are: taste 3.9, texture: 4.72, total solids: 35.13%, protein: 13.45 %and fat: 14.05%.