Background: Knee is one of the important joints of the body, and osteoarthritis is the most common disease of this joint. It causes pain, swelling, limited mobility and other functional disabilities. Several therapeutic approaches, including drug therapy, physiotherapy, and surgical treatments such as arthroscopic debridement and knee replacement have been used for this disease. Knee replacement is one of the most effective treatments for this disease. Method: In a clinical prospective study, 57 patients who had undergone knee replacement in one year period in a teaching hospital were evaluated before and after surgery with a mean follow-up of 7.3 months. VAS, WOMAC, KSS, and SF-36 questionnaires were completed for all. The postoperative radiographs were analyzed using KSRE form. Results: From the 57 patients that were studied, 51 were female and 6 male. The mean age at surgery was 62.5 years (45-82 years) evaluated, on average, 7.31 months after the operation. Based on the KSS form, the mean" Function score" increased from 15.27±24.03 before surgery to 69.96±8.93 after surgery; and the mean "Knee score" from 7.58±40.43 to 82.38±7.03. The mean WOMAC score decreased from 69.02±11.02 to 25.73±5.92 and the pain score decreased from 8.89±0.77 before surgery to 1.54±1.00 after surgery. The mean SF-36 score increased from 45.75±18.85 before surgery to 65.26±17.86 after surgery. The postoperative radiographic imaging showed a mean alpha angle of 97.8±0.98, beta angle of 89.7±1.11, gamma angle of 2.57±1.62, and the mean delta angle of 86.38±0.81.Conclusion: Due to the significant improvement in pain, WOMAC score, knee score, range of motion and quality of life in this short term study, the knee replacement surgery is considered an effective treatment for osteoarthritis of the knee in the group we studied.