The relationship between natural valuability and gender is among the basic researches whose results influence on a vast range of theories about women’s issues. In this paper, after presenting a definition and classification of natural valuability outside the realm of ethics and referring to some value foundations in anthropology, infrastructural orientations of the issue are determined. Then, on the basis of strong narrational arguments, the relationship is explained with reference to the Quran. Afterwards, on the basis of a philosophical approach, the paper studies essence, essentials, and the difference of man, the evaluation of the impacts of gender on it, since the most original and valuable gift of man is reason. As a result, the relationship between conceptual powers and levels of reason with gender are also explained. Then, on the basis of Mulla Sadra’s theory of Motion of Essence, the levels of the relationship between spirit and gender and the mutual impact of soul and body are explained. Finally, on the basis of a monotheist and Quranic approach, the natural valuability of woman is depicted in a different atmosphere.