INHIBITORY EFFECT OF ZIZIPHORA CLINOPODIOIDES LAM. ON RAT’S GASTRIC ACID SECRETION IN BASAL, VAGOTOMIZED AND VAGAL STIMULATED CONDITIONS

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NIAZMAND SAEID; ERFANIAN AHMADPOUR M.; HAJZADEH M.A.R.; HOSSEINI KH.

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Journal: Razi Journal of Medical Sciences Year:2009 | Volume:16 | Issue:63 Page(s): 162-168

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Title

INHIBITORY EFFECT OF ZIZIPHORA CLINOPODIOIDES LAM. ON RAT’S GASTRIC ACID SECRETION IN BASAL, VAGOTOMIZED AND VAGAL STIMULATED CONDITIONS

Author(s)

NIAZMAND SAEID | ERFANIAN AHMADPOUR M. | HAJZADEH M.A.R. | HOSSEINI KH. | Issue Writer Certificate

Keywords

ZIZIPHORA CLINOPODIOIDES LAMQ3

GASTRIC ACIDQ3

VAGOTOMYQ3

VAGOUS NERVEQ3

Abstract

Background & Aim: ZIZIPHORA CLINOPODIOIDES LAM. is a plant widely used in Iranian traditional medicine. Several reports have demonstrated antibacterial, antioxidant and anti-inflammatory properties of Ziziphora clinopodioides. The aim of this study is to investigate the effects of aqueous-ethanol extract of Ziziphora clinopodioides on rat’s GASTRIC ACID secretion and its probable mechanism. Material and Method: In this interventional experimental study, 24 Wistar rats weighing 200-250g were randomly divided into two groups: test and control. Tracheostomy and gastroduodenostomy procedures were performed on each rat. Gastric content was collected for 15 minutes by washout technique. 1 ml of three dosages (0. 5, 1 and 2 mg/kg) was introduced into the stomach of each rat in the test group and the same volume of saline was used in the control group. Total titratable acid was measured by a titrator. Data were shown as mean±SEM and analyzed by unpaired t-test. P<0. 05 were considered significant.Results: The extract inhibited acid secretion significantly in basal condition, but in vagotomized condition this inhibitory effect on acid secretion disappeared and the extract showed a stimulatory effect at the dose of 2mg/kg. Also, the extract showed an inhibitory effect at the dose of 1mg/kg in vagal stimulation condition.Conclusion: The extract exerted an inhibitory effect on acid secretion in basal and vagal stimulation conditions. The inhibitory effect of the extract was exerted via gastric vagal parasympathetic nerve.

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APA: Copy

NIAZMAND, SAEID, ERFANIAN AHMADPOUR, M., HAJZADEH, M.A.R., & HOSSEINI, KH.. (2009). INHIBITORY EFFECT OF ZIZIPHORA CLINOPODIOIDES LAM. ON RAT’S GASTRIC ACID SECRETION IN BASAL, VAGOTOMIZED AND VAGAL STIMULATED CONDITIONS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 16(63), 162-168. SID. https://sid.ir/paper/10040/en

Vancouver: Copy

NIAZMAND SAEID, ERFANIAN AHMADPOUR M., HAJZADEH M.A.R., HOSSEINI KH.. INHIBITORY EFFECT OF ZIZIPHORA CLINOPODIOIDES LAM. ON RAT’S GASTRIC ACID SECRETION IN BASAL, VAGOTOMIZED AND VAGAL STIMULATED CONDITIONS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2009;16(63):162-168. Available from: https://sid.ir/paper/10040/en

IEEE: Copy

SAEID NIAZMAND, M. ERFANIAN AHMADPOUR, M.A.R. HAJZADEH, and KH. HOSSEINI, “INHIBITORY EFFECT OF ZIZIPHORA CLINOPODIOIDES LAM. ON RAT’S GASTRIC ACID SECRETION IN BASAL, VAGOTOMIZED AND VAGAL STIMULATED CONDITIONS,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 16, no. 63, pp. 162–168, 2009, [Online]. Available: https://sid.ir/paper/10040/en

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