EVALUATION THE EFFECT OF RUMEX ALCOHOLIC EXTRACT AGAINST CUTANEOUS LEISHMANIASIS CAUSED BY LEISHMANIA MAJOR IN BALB/C MICE

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NURSABAGHI FARZAD; ABEDINZADE MAHMOOD; JALALLOU NAHID

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Journal: Razi Journal of Medical Sciences Year:2016 | Volume:23 | Issue:148 Page(s): 28-35

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Title

EVALUATION THE EFFECT OF RUMEX ALCOHOLIC EXTRACT AGAINST CUTANEOUS LEISHMANIASIS CAUSED BY LEISHMANIA MAJOR IN BALB/C MICE

Author(s)

NURSABAGHI FARZAD | ABEDINZADE MAHMOOD | JALALLOU NAHID | Issue Writer Certificate

Keywords

CUTANEOUS LEISHMANIASISQ3

LEISHMANIA MAJORQ2

RUMEXQ1

MICE BALB/CQ2

Abstract

Background: CUTANEOUS LEISHMANIASIS is an endemic disease in many countries, including Iran. Pentavalent antimony compounds used to treat this disease is associated with adverse effects for patients. The aim of this study was to evaluate the effectiveness of the alcoholic extract of RUMEX on experimental lesion of LEISHMANIA MAJOR in BALB/c mice.Methods: In this study, thirty mice were divided into 6 groups A to F, 5 mice in each group, and then inoculated subcutaneously at the base of the tail with 100 micro liter liquid phase culture containing promastigotes (1´106) of active LEISHMANIA MAJOR promastigotes standard strain (MRHO/IR/75/ER). Cutaneous lesions were appeared approximately after 3 weeks. Three different concentrations of RUMEX seeds alcoholic extract (0.3, 0.5 and 0.9) were used as an injection to Group D-F. Three other groups were considered as control; group A received no treatment, groups B and C were received ethanol alone and glucantime, respectively. All injections were performed 2 times a day for 15 days and every week the lesion diameter was measured in all groups. The number of parasites in the lesions stained smears were examined under a microscope. Information were recorded and analyzed using one-away ANOVA and post-hoc Tukey’s test.Results: The mean diameter of lesions decreased in concentration of 9mg/ml after 5 week and complete healing was observed in this group. Also the parasitic load was decreased significantly in comparison with glucantime injected group (p£0.05).Conclusions: The results suggest that the effective concentration of the herbs mentioned in this article (9mg/ml) could be used as an appropriate alternative medicine on human CUTANEOUS LEISHMANIASIS.

Cites

The mechanism of action of methanolic extract of Rumex alveolatus on the membranes of Candida albicans, Candida paraposilosis and Candida glabratata

References

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APA: Copy

NURSABAGHI, FARZAD, ABEDINZADE, MAHMOOD, & JALALLOU, NAHID. (2016). EVALUATION THE EFFECT OF RUMEX ALCOHOLIC EXTRACT AGAINST CUTANEOUS LEISHMANIASIS CAUSED BY LEISHMANIA MAJOR IN BALB/C MICE. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 23(148), 28-35. SID. https://sid.ir/paper/10197/en

Vancouver: Copy

NURSABAGHI FARZAD, ABEDINZADE MAHMOOD, JALALLOU NAHID. EVALUATION THE EFFECT OF RUMEX ALCOHOLIC EXTRACT AGAINST CUTANEOUS LEISHMANIASIS CAUSED BY LEISHMANIA MAJOR IN BALB/C MICE. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2016;23(148):28-35. Available from: https://sid.ir/paper/10197/en

IEEE: Copy

FARZAD NURSABAGHI, MAHMOOD ABEDINZADE, and NAHID JALALLOU, “EVALUATION THE EFFECT OF RUMEX ALCOHOLIC EXTRACT AGAINST CUTANEOUS LEISHMANIASIS CAUSED BY LEISHMANIA MAJOR IN BALB/C MICE,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 23, no. 148, pp. 28–35, 2016, [Online]. Available: https://sid.ir/paper/10197/en

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