EXPRESSION OF MHC CLASS I AND ICAM-I ASSOCIATION BETWEEN BREAST CANCER AND HYPERPLASIA BIOPSY SPECIMEN IN WOMEN AGED BETWEEN 35-65 YEARS BY INDIRECT IMMUNOFLUORESCENCE

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ENTEZAMI K.; SHAH GHASEMPOUR SHAPOUR; RAKHSHAN M.; NIKRAH E.

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Journal: Razi Journal of Medical Sciences Year:2005 | Volume:12 | Issue:48 (SPECIAL ISSUE) Page(s): 27-34

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Title

EXPRESSION OF MHC CLASS I AND ICAM-I ASSOCIATION BETWEEN BREAST CANCER AND HYPERPLASIA BIOPSY SPECIMEN IN WOMEN AGED BETWEEN 35-65 YEARS BY INDIRECT IMMUNOFLUORESCENCE

Author(s)

ENTEZAMI K. | SHAH GHASEMPOUR SHAPOUR | RAKHSHAN M. | NIKRAH E. | Issue Writer Certificate

Keywords

MAJOR HISTOCOMPATIBILITY-I(MHC-I) - INTRACELLULAR ADHESION MOLECULE-I(ICAM-I) - BREAST CANCERQ4

Abstract

Background & Aim: Major histocompatibility complex(MHC) class one and intercellular adhesion molecule-I(ICAM-I) play important roles in immune response. It is well known that the expression level of the MHC class I and ICAM-I is frequently altered in accordance with tumor progression and is significantly related to tumorigenesis, tumor progression, and/or metastatic potential(e.g.kidney and prostate cancers). The aim of this study was based on the hypothesis that decreased or absent expression of MHC class I and ICAM-I surface antigens or costimulatory molecules on tumor cells might be responsible, in part, for the progression of breast cancer.Patients & Methods: To investigate the expression level of above molecules, 25 breast cancer and 25 breast hyperplasia cells samples from women aged between 35-65 years were obtained. Then, biopsy specimens from samples were prepared. Indirect immunofluorescence technique and H&E staining were used.Results: Immunohistochemical and pathological analysis in this study revealed a negative correlation between the expression of MHC-I and ICAM-I surface antigens and grade (differentiation) of breast cancer was compared with breast benign hyperplasia cell samples. Results were expressed as the mean±SD. Student’s t-test and SPSS program were used to assess the differences, and a significant level of P<0.00 was found.Conclusion: In general, tumor with higher grade(cell differentiation) expressed MHC class I and ICAM-I sufraceantigens on breast cancer cell less frequently and intensely. The absence or decreased level of MHC and ICAM-I surface antigen expression on women breast cancer cells is responsible for tumor progression.

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APA: Copy

ENTEZAMI, K., SHAH GHASEMPOUR, SHAPOUR, RAKHSHAN, M., & NIKRAH, E.. (2005). EXPRESSION OF MHC CLASS I AND ICAM-I ASSOCIATION BETWEEN BREAST CANCER AND HYPERPLASIA BIOPSY SPECIMEN IN WOMEN AGED BETWEEN 35-65 YEARS BY INDIRECT IMMUNOFLUORESCENCE. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 12(48 (SPECIAL ISSUE)), 27-34. SID. https://sid.ir/paper/10437/en

Vancouver: Copy

ENTEZAMI K., SHAH GHASEMPOUR SHAPOUR, RAKHSHAN M., NIKRAH E.. EXPRESSION OF MHC CLASS I AND ICAM-I ASSOCIATION BETWEEN BREAST CANCER AND HYPERPLASIA BIOPSY SPECIMEN IN WOMEN AGED BETWEEN 35-65 YEARS BY INDIRECT IMMUNOFLUORESCENCE. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2005;12(48 (SPECIAL ISSUE)):27-34. Available from: https://sid.ir/paper/10437/en

IEEE: Copy

K. ENTEZAMI, SHAPOUR SHAH GHASEMPOUR, M. RAKHSHAN, and E. NIKRAH, “EXPRESSION OF MHC CLASS I AND ICAM-I ASSOCIATION BETWEEN BREAST CANCER AND HYPERPLASIA BIOPSY SPECIMEN IN WOMEN AGED BETWEEN 35-65 YEARS BY INDIRECT IMMUNOFLUORESCENCE,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 12, no. 48 (SPECIAL ISSUE), pp. 27–34, 2005, [Online]. Available: https://sid.ir/paper/10437/en

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