COMPARISON OF ANTICANCER EFFECTS OF NANOCAPSULES OF NASTURTIUM OFFICINALIS (L.) R. BR. EXTRACT WITH METHANOLIC EXTRACT AND ITS FRACTIONS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SEFIDKON F.; TORABI SAGVAND B.; NADERI M.; GHUSHEGIR S.A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS Year:2013 | Volume:29 | Issue:1 (59) Page(s): 35-50

Download Full-Text

Persian Verion

View:

1,711

Download:

Cites:

Information Journal Paper

Title

COMPARISON OF ANTICANCER EFFECTS OF NANOCAPSULES OF NASTURTIUM OFFICINALIS (L.) R. BR. EXTRACT WITH METHANOLIC EXTRACT AND ITS FRACTIONS

Author(s)

SEFIDKON F. | TORABI SAGVAND B. | NADERI M. | GHUSHEGIR S.A. | Issue Writer Certificate

Keywords

NASTURTIUM OFFICINALIS (L.) R. BR.Q2

EXTRACTQ2

NANOCAPSULEQ2

COLON CANCERQ2

BREAST CANCERQ2

Abstract

Nasturtium officinalis (L.) R. Br. is a prennial and aquatic plant which grows in water flows of most regions of Iran. There are flavonoids in the leaves and flowers of N. officinalis with anticancer properties. In this research, to investigate anticancer effects, leaves and flowers of N. officinalis were used by maceration in methanol for preparation of EXTRACT and its fractions. Also, the EXTRACT was converted to NANOCAPSULEs. The fractions of dichloromethane, diethylether and methanol were prepared from the first EXTRACT. NANOCAPSULEs were prepared by double emulsion method using poly-lactic-glycolic acid. NANOCAPSULEs were dried and their dimensions and distribution coefficient were determined. To evaluate the inhibitory effects on the proliferation of BREAST CANCER cells (T47D) and COLON CANCER cells (HT-29), effects of the first EXTRACT, fractions and NANOCAPSULEs were compared with Doxorubicin (500 nM) and RPMI as control treatment. Measuring the the average size of NANOCAPSULEs showed that the dimentions of 50% of NANOCAPSULEs were less than 10 nm and the other were between 50-900 nm. Results of anticancer properties of the EXTRACT and fractions of N. officinalis on both breast and COLON CANCER cells, for 1 to 3 days, showed that dichloromethane fraction had a stronger effect on inhibition of proliferation of cancer cells compared to the first EXTRACT and other fractions. In addition, NANOCAPSULEs in the same concentration and period of time killed more cells in comparison to the first EXTRACT. Meanwhile, the anticancer effect of N. officinalis EXTRACT on BREAST CANCER cells was stronger than that on COLON CANCER cells. Consequently, the possibility of making medicines from this plant EXTRACT especially in NANOCAPSULE form could be considered.

Cites

References

No record.

Cite

APA: Copy

SEFIDKON, F., TORABI SAGVAND, B., NADERI, M., & GHUSHEGIR, S.A.. (2013). COMPARISON OF ANTICANCER EFFECTS OF NANOCAPSULES OF NASTURTIUM OFFICINALIS (L.) R. BR. EXTRACT WITH METHANOLIC EXTRACT AND ITS FRACTIONS. IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS, 29(1 (59)), 35-50. SID. https://sid.ir/paper/104883/en

Vancouver: Copy

SEFIDKON F., TORABI SAGVAND B., NADERI M., GHUSHEGIR S.A.. COMPARISON OF ANTICANCER EFFECTS OF NANOCAPSULES OF NASTURTIUM OFFICINALIS (L.) R. BR. EXTRACT WITH METHANOLIC EXTRACT AND ITS FRACTIONS. IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS[Internet]. 2013;29(1 (59)):35-50. Available from: https://sid.ir/paper/104883/en

IEEE: Copy

F. SEFIDKON, B. TORABI SAGVAND, M. NADERI, and S.A. GHUSHEGIR, “COMPARISON OF ANTICANCER EFFECTS OF NANOCAPSULES OF NASTURTIUM OFFICINALIS (L.) R. BR. EXTRACT WITH METHANOLIC EXTRACT AND ITS FRACTIONS,” IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS, vol. 29, no. 1 (59), pp. 35–50, 2013, [Online]. Available: https://sid.ir/paper/104883/en

Related Journal Papers