ANTI-PROLIFERATIVE EFFECTS OF SOME FRACTIONS OF ELAEAGNUS ANGUSTIFOLIA L. FLOWER AND AERIAL PART OF NEPETA CRISPA L. ON K562 LEUKEMIC CELLS

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BADRHADAD A.; PIRI KH.; MANSOURI K.

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Journal: IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS Year:2015 | Volume:31 | Issue:5 (73) Page(s): 881-890

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Title

ANTI-PROLIFERATIVE EFFECTS OF SOME FRACTIONS OF ELAEAGNUS ANGUSTIFOLIA L. FLOWER AND AERIAL PART OF NEPETA CRISPA L. ON K562 LEUKEMIC CELLS

Author(s)

BADRHADAD A. | PIRI KH. | MANSOURI K. | Issue Writer Certificate

Keywords

ELAEAGNUS ANGUSTIFOLIA L.Q2

NEPETA CRISPA L.Q2

FRACTIONSQ2

K562 LEUKEMIC CELLSQ2

ANTIPROLIFERATIVEQ2

Abstract

Previous studies have shown an anti-tumoral effect for different species of plant having similar component with ELAEAGNUS ANGUSTIFOLIA L.and NEPETA CRISPA L. on cancer cells. This study was performed to evaluate the anti-tumural effects of Elagnus angustifolia and Nepeta crispa extracts on leukemia cancer cells. Cancer cells, grown in DMEM/F12 culture medium, were supplemented with fetal calf serum, 100U/ml penicillin and 100mg/ml streptomycint, then incubation at 37oC in a 5% CO2. The FRACTIONS of Hexane, ethyl acetate, chloroform and aquesse at 10-160 mg/ml concentration were applied on K562 LEUKEMIC CELLS, and their effects were evaluated on proliferation and viability of cells by cell counter and LDH kits, respectively. Result showed that chloroform (chf), ethylacetate (EA) FRACTIONS of Elaeagnus angustifolia and Nepeta crispa showed an important cytotoxic effect on K562 cells. Isolated extracts from E. angustifolia flower and N. crispa caused a significant decrease in lukemia cancer cell growth. Therefore, this plant could be candidate for therapeutic or preventive activity against cancerrelated disorders. Isolation and purification of effective compound/s from this extract and determination of their mechanisms of action are suggested.

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APA: Copy

BADRHADAD, A., PIRI, KH., & MANSOURI, K.. (2015). ANTI-PROLIFERATIVE EFFECTS OF SOME FRACTIONS OF ELAEAGNUS ANGUSTIFOLIA L. FLOWER AND AERIAL PART OF NEPETA CRISPA L. ON K562 LEUKEMIC CELLS. IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS, 31(5 (73)), 881-890. SID. https://sid.ir/paper/105474/en

Vancouver: Copy

BADRHADAD A., PIRI KH., MANSOURI K.. ANTI-PROLIFERATIVE EFFECTS OF SOME FRACTIONS OF ELAEAGNUS ANGUSTIFOLIA L. FLOWER AND AERIAL PART OF NEPETA CRISPA L. ON K562 LEUKEMIC CELLS. IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS[Internet]. 2015;31(5 (73)):881-890. Available from: https://sid.ir/paper/105474/en

IEEE: Copy

A. BADRHADAD, KH. PIRI, and K. MANSOURI, “ANTI-PROLIFERATIVE EFFECTS OF SOME FRACTIONS OF ELAEAGNUS ANGUSTIFOLIA L. FLOWER AND AERIAL PART OF NEPETA CRISPA L. ON K562 LEUKEMIC CELLS,” IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS, vol. 31, no. 5 (73), pp. 881–890, 2015, [Online]. Available: https://sid.ir/paper/105474/en

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