Semi-parametric and parametric survival analysis of patients with beta thalassemia major

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Riyahifar Sevda; AZADI NAMAM ALI; AZARKEIVAN AZITA; ABOLGHASEMI JAMILEH; ASHOURI ASIEH; Hasanzadeh Parvin; RASOULI MAHBOOBEH

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Journal: Razi Journal of Medical Sciences Year:2018 | Volume:25 | Issue:8 Page(s): 62-73

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Title

Semi-parametric and parametric survival analysis of patients with beta thalassemia major

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Keywords

Survival analysisQ2

Parametric Weibull modelQ1

Semi-parametric Cox modelQ1

Akaike Information criterionQ1

Beta-thalassemia majorQ3

Abstract

Background: Beta-thalassemia major is a very severe blood disease, its Clinical signs are premature and appear from 3 to 6 months of age. It is one of the most common monogenic diseases in the world and in Iran, and if it is not diagnosed and treated during the first years of life, it will lead to death. In this study, to check the factors affecting the survival of patients with Beta-thalassemia major the semi-parametric Cox and Parametric Weibull models were used and their efficiency was compared. Methods: In this longitudinal retrospective study, using the available sampling method, data from 300 patients with Beta-thalassemia major referred to Zafar's thalassemia clinic in Tehran during the years 1994 to 2017 were used. To compare the models and select the best model, we used the Akaike Information criterion (AIC). Data analysis was performed using Stata software version 13. Results: The values of the Akaike Information criterion (AIC) for Semi-parametric Cox model and the Parametric Weibull model were 277. 600 and 107. 211, respectively. Based on both Cox and Weibull models, the variables of blood transfusion, age of desferal and iron deposition in the liver were significantly associated with the survival of patients. Based on Akaike's criterion, the efficiency of the Weibull model was better than the Cox model. Conclusion: Considering the obtained values, the Parametric Weibull model is more efficient than the Semi-parametric Cox model for Survival analysis of patients with betathalassemia major.

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Parametric and semi parametric survival analysis of patients with lung cancer

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APA: Copy

Riyahifar, Sevda, AZADI, NAMAM ALI, AZARKEIVAN, AZITA, ABOLGHASEMI, JAMILEH, ASHOURI, ASIEH, Hasanzadeh, Parvin, & RASOULI, MAHBOOBEH. (2018). Semi-parametric and parametric survival analysis of patients with beta thalassemia major. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 25(8 ), 62-73. SID. https://sid.ir/paper/10573/en

Vancouver: Copy

Riyahifar Sevda, AZADI NAMAM ALI, AZARKEIVAN AZITA, ABOLGHASEMI JAMILEH, ASHOURI ASIEH, Hasanzadeh Parvin, RASOULI MAHBOOBEH. Semi-parametric and parametric survival analysis of patients with beta thalassemia major. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2018;25(8 ):62-73. Available from: https://sid.ir/paper/10573/en

IEEE: Copy

Sevda Riyahifar, NAMAM ALI AZADI, AZITA AZARKEIVAN, JAMILEH ABOLGHASEMI, ASIEH ASHOURI, Parvin Hasanzadeh, and MAHBOOBEH RASOULI, “Semi-parametric and parametric survival analysis of patients with beta thalassemia major,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 25, no. 8 , pp. 62–73, 2018, [Online]. Available: https://sid.ir/paper/10573/en

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