THE DIAGNOSTIC VALUE OF INSULIN-LIKE GROWTH FACTOR (IGF) – 1 AND IGF-BINDING PROTEIN-3 IN THE EVALUATION OF CHILDREN WITH SHORT STATURE AND SUSPECTED GROWTH HORMONE DEFICIENCY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HAGHSHENAS Z.; KARAMIFAR H.; KARAMIZADEH Z.; AMIR HAKIMI G.H.; SOTOUDEH K.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF MEDICAL RESEARCH (JMR) Year:2005 | Volume:3 | Issue:4 Page(s): 67-79

Download Full-Text

Persian Verion

View:

2,098

Download:

Cites:

Information Journal Paper

Title

THE DIAGNOSTIC VALUE OF INSULIN-LIKE GROWTH FACTOR (IGF) – 1 AND IGF-BINDING PROTEIN-3 IN THE EVALUATION OF CHILDREN WITH SHORT STATURE AND SUSPECTED GROWTH HORMONE DEFICIENCY

Author(s)

Keywords

GROWTH HORMONE DEFICIENCYQ3

IGF-1Q4

IGFBP-3Q4

SHORT STATUREQ4

Abstract

Background: The purpose of this study was to evaluate the diagnostic value of IGF-1 and IGFBP-3 in the evaluation of children and adolescents with SHORT STATURE in whom GROWTH HORMONE DEFICIENCY (GHD) was suspected. Materials and Methods: In this case series study, children and adolescents with SHORT STATURE who were referred to Nemazee Hospital in Shiraz in 2003 were studied. Inclusion criteria included proved SHORT STATURE based on physical examination, weight, height and standard deviation score (SDS) of height < -2 , sexual maturity and predicted height in normal children without any genetic or chronic disorders. The exclusion criteria included any positive physical or laboratory data suggesting hypothyroidism, rickets or liver disorders. For all patients a provocative growth hormone test was performed with propranolol and L-dopa and serum IGF-1 and IGFBP-3 levels were measured. Suspected GHD was defined as a peak (cut-off) serum GH level less than 10 μg/L while low IGF-1 and IGFBP-3 was considered as a cut-off serum level under two standard deviations. Results: Eighty-one patients with SHORT STATURE (39 boys and 42 girls) with a mean age of 10.6±3.5 years completed the study. Seventeen patients with suspected GHD were found and in 18 patients IGF-1 level was low. Only in 6 patients GH and IGF-1 were both low and among them 2 patients also had a low IGFBP-3. There was no correlation between levels of GH in cases suspected of GHD with IGF-1 as well as IGFBP-3 levels. The sensitivity and specificity of IGF-1 and IGFBP-3 in the assessment of suspected GHD cases were 35 and 81 percent for IGF-1 and 12 and 94 percent for IGFBP-3, respectively. Conclusion: No correlation was found between the level of GH in patients with suspected GHD and serum levels of IGF-1 and IGFBP-3 in short patients and the sensitivity of these tests in the assessment of suspected GHD patients was poor.

Cites

No record.

References

No record.

Cite

APA: Copy

HAGHSHENAS, Z., KARAMIFAR, H., KARAMIZADEH, Z., AMIR HAKIMI, G.H., & SOTOUDEH, K.. (2005). THE DIAGNOSTIC VALUE OF INSULIN-LIKE GROWTH FACTOR (IGF) – 1 AND IGF-BINDING PROTEIN-3 IN THE EVALUATION OF CHILDREN WITH SHORT STATURE AND SUSPECTED GROWTH HORMONE DEFICIENCY. JOURNAL OF MEDICAL RESEARCH (JMR), 3(4), 67-79. SID. https://sid.ir/paper/105826/en

Vancouver: Copy

HAGHSHENAS Z., KARAMIFAR H., KARAMIZADEH Z., AMIR HAKIMI G.H., SOTOUDEH K.. THE DIAGNOSTIC VALUE OF INSULIN-LIKE GROWTH FACTOR (IGF) – 1 AND IGF-BINDING PROTEIN-3 IN THE EVALUATION OF CHILDREN WITH SHORT STATURE AND SUSPECTED GROWTH HORMONE DEFICIENCY. JOURNAL OF MEDICAL RESEARCH (JMR)[Internet]. 2005;3(4):67-79. Available from: https://sid.ir/paper/105826/en

IEEE: Copy

Z. HAGHSHENAS, H. KARAMIFAR, Z. KARAMIZADEH, G.H. AMIR HAKIMI, and K. SOTOUDEH, “THE DIAGNOSTIC VALUE OF INSULIN-LIKE GROWTH FACTOR (IGF) – 1 AND IGF-BINDING PROTEIN-3 IN THE EVALUATION OF CHILDREN WITH SHORT STATURE AND SUSPECTED GROWTH HORMONE DEFICIENCY,” JOURNAL OF MEDICAL RESEARCH (JMR), vol. 3, no. 4, pp. 67–79, 2005, [Online]. Available: https://sid.ir/paper/105826/en

Related Journal Papers